聚乙二醇结合牛血红蛋白（PEG-bHb）在大鼠中的药效学研究。,Artificial Cells, Blood Substitutes, and Biotechnology

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聚乙二醇结合牛血红蛋白（PEG-bHb）在大鼠中的药效学研究。
Artificial Cells, Blood Substitutes, and Biotechnology Pub Date : 2004-07-28 , DOI: 10.1081/bio-120037826
Zhigang Bi ₁ , Xueying He , Xiaowei Zhang , Yong Jiang , Kesen Zhao , Qian Liu

Affiliation

这项研究的目的是确定聚乙二醇（PEG）偶联在无基质牛血红蛋白，出血性休克和交换输血大鼠模型中的药效学。在两种大鼠模型中，经6％PEG-bHb处理的动物的血压升高均显着高于右旋糖酐70，甚至高于全血（等体积出血）输血。6％的PEG-BHb可以显着改善实验动物的微循环，包括降低血液粘度和改善血流。PEG-bHb的这种作用优于自体血液，后者只能恢复50％的血流，而当使用等体积的葡聚糖70时，对血流没有影响。使用Oxyspot荧光计通过磷的氧依赖性猝灭来评估大鼠的组织氧合，结果表明，PEG-bHb的输氧能力接近自体血液，优于右旋糖酐70。基于这些作用，PEG-bHb治疗的动物的存活率接近全血。并且数据表明，出血的一半是合理的治疗剂量。总之，PEG-bHb是一种有效的血液替代品，具有强大的组织氧合作用和血容量扩展功能。

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Pharmacodynamic study of polyethylene glycol conjugated bovine hemoglobin (PEG-bHb) in rats.

The purpose of this study was to determine the pharmacodynamics of polyethylene glycol (PEG) conjugation on stroma-free bovine hemoglobin, hemorrhage shock, and exchange transfusion rat models were used. In both rat models, blood pressure increased in 6% PEG-bHb treated animals was significantly higher than dextran 70, even than whole blood (isovolume of hemorrhage) transfusion. Six percent PEG-BHb could ameliorate the micro-circulation of the experimental animals markedly, including reducing the blood viscosity and improving the blood flow. This effect of PEG-bHb was superior to autogenous blood which only recovered 50% blood flow, and there's no effect on blood flow when used isovolumic dextran 70. Tissue oxygenations of rats were evaluated by the oxygen dependent quenching of phosphorescence using an Oxyspot phosphorimeter, and the results showed that capability of oxygen-delivery of PEG-bHb was close to autogenous blood and superior to dextran 70. Based on these effects, the survival rates of animals treated with PEG-bHb were close to that of the whole blood transfusion. And data suggested that half of the hemorrhage transfusion is the reasonable therapeutic dosage. In conclusion, PEG-bHb is an effective blood substitute with powerful tissue oxygenation and blood volume expansion.

更新日期：2019-11-01

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