A new series of quinoxalinones 6/7-trifluoromethyl or nitro- and 6,7-difluoro substituted bearing various side-chains (alkyl, halogenoalkyl, benzyl and phenyl groups) at C-3 of the ring system was synthesized and submitted to preliminary in vitro evaluation for antibacterial, antifungal, antimycobacterial, anticancer and anti-HIV activities. Results of these screenings showed that compounds 23-28 exhibited a good inhibition activity against various strains of Candida. Compound 24 showed also an interesting in vitro anticancer activity.

中文翻译：

---

6 / 7-三氟甲基（硝基）-，6,7-二氟-3-烷基（芳基）取代的喹喔啉-2-酮的制备和生物学评价。第三部分

合成了在环系统C-3上带有各种侧链（烷基，卤代烷基，苄基和苯基）的一系列新的喹喔啉酮6 / 7-三氟甲基或硝基和6,7-二氟取代基，并准备在体外评估抗菌，抗真菌，抗分枝杆菌，抗癌和抗HIV活性。这些筛选的结果表明，化合物23-28显示出对各种念珠菌菌株的良好抑制活性。化合物24还显示出令人感兴趣的体外抗癌活性。