2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.

中文翻译：

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具有降血压性质的天然2'-O-甲基嘌呤核苷。

首次分离出2'-O-甲基肌苷（1），这是一种固有的降压原理。其可能的体内前体2'-O-甲基腺苷（3）表现出更强甚至口服的降压活性。认为甲基腺苷（3）对腺苷脱氨酶的抗性有助于其持久的活性。两种核苷（1和3）的作用都没有伴随心率的任何显着变化，这通常在腺苷中观察到。