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Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties.
Cellular and Molecular Life Sciences ( IF 6.2 ) Pub Date : 1998-04-16 , DOI: 10.1007/s000180050131 T Yamada 1 , K Kageyama , Y Joh , J Konishi , K Ienaga
Cellular and Molecular Life Sciences ( IF 6.2 ) Pub Date : 1998-04-16 , DOI: 10.1007/s000180050131 T Yamada 1 , K Kageyama , Y Joh , J Konishi , K Ienaga
Affiliation
2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.
中文翻译:
具有降血压性质的天然2'-O-甲基嘌呤核苷。
首次分离出2'-O-甲基肌苷(1),这是一种固有的降压原理。其可能的体内前体2'-O-甲基腺苷(3)表现出更强甚至口服的降压活性。认为甲基腺苷(3)对腺苷脱氨酶的抗性有助于其持久的活性。两种核苷(1和3)的作用都没有伴随心率的任何显着变化,这通常在腺苷中观察到。
更新日期:2019-11-01
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
具有降血压性质的天然2'-O-甲基嘌呤核苷。
首次分离出2'-O-甲基肌苷(1),这是一种固有的降压原理。其可能的体内前体2'-O-甲基腺苷(3)表现出更强甚至口服的降压活性。认为甲基腺苷(3)对腺苷脱氨酶的抗性有助于其持久的活性。两种核苷(1和3)的作用都没有伴随心率的任何显着变化,这通常在腺苷中观察到。