2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.

中文翻译：

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天然存在的 2'-O-甲基嘌呤核苷具有降血压特性。


2'-O-甲基肌苷 (1) 首次被分离出来，并被证明是一种内在的降血压原理。其可能的体内前体 2'-O-甲基腺苷 (3) 显示出更强且甚至口服有效的降血压活性。甲基腺苷 (3) 对腺苷脱氨酶的抵抗被认为有助于其持久的活性。两种核苷（1 和 3）的作用并不伴随心率的任何显着变化，而腺苷经常观察到这种情况。