一项研究储存的供血中钠和钾离子浓度的变化及其对受体电解质平衡的影响。,BioMed Research International

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一项研究储存的供血中钠和钾离子浓度的变化及其对受体电解质平衡的影响。
BioMed Research International ( IF 2.6 ) Pub Date : 2019-09-29 , DOI: 10.1155/2019/8162975
Samuel Antwi-Baffour ₁ , Jonathan Kofi Adjei ₁ , Felix Tsyawo ₂ , Ransford Kyeremeh ₁ , Felix Abekah Botchway ₃ , Mahmood Abdulai Seidu ₁

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背景。保存的血细胞在输血后经历可能影响其功能、完整性和活力的进行性结构和功能变化。输血对受血者钾、钠或酸碱平衡的影响可能很复杂，但相关信息却不一致。因此，本研究试图确定在 4°C 下储存 28 天的全血中钾和钠水平的变化以及输血时的临床结果。方法. 将全血放入双 CPDA-1 袋中，并将 50 毫升转移到卫星袋中用于研究。使用 Vitalab Selectra Junior 化学分析仪在第 0、7、14、21 和 28 天对每个血样进行电解质浓度测定。28天后输注主袋中剩余的血液，并对输血前后的患者进行生化分析。单因素方差分析用于分析从患者获得的数据的每周离子浓度和独立样本 Mann-Whitney U检验之间的方差。结果. 所有样本的平均钾水平从第一天的正常值 3.45 mmol/L 开始，随后在第 7 天急剧上升至 9.40 mmol/L，第 14 天为 13.40 mmol/L，第 14.60 mmol/L 21，第 28 天 15.40 mmol/L。另一方面，钠在第 0 天开始为 148.4 mmol/L 的高值，然后在第 7 天降至 146.4 mmol/L，第 14 天为 140.8 mmol/L，135.6第21天为130.8 mmol/L，第28天为130.8 mmol/L。患者输血后未见不良临床结局。结论。可以推断，冷冻血液中的钾浓度会随着时间的推移而增加，而钠浓度会随着时间的推移而降低，并且在输注这种血液时，可能不会导致任何不良的临床结果。

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A Study of the Change in Sodium and Potassium Ion Concentrations in Stored Donor Blood and Their Effect on Electrolyte Balance of Recipients.

Background. Preserved blood cells undergo progressive structural and functional changes that may affect their function, integrity, and viability after transfusion. The impact of transfusion of stored blood on potassium, sodium, or acid-base balance in the recipient may be complex, but information on it is inconsistent. This study therefore sought to determine the changes in the potassium and sodium levels in whole blood stored at 4°C for 28 days and clinical outcomes when such blood are transfused. Methods. Whole blood were taken into double CPDA-1 bags and 50 ml transferred into the satellite bags for the study. Electrolyte concentration determinations were made on each of the blood sample on days 0, 7, 14, 21, and 28 using the Vitalab Selectra Junior chemistry analyser. The remaining blood in the main bags was transfused after the 28-day period, and biochemical analysis carried out on the patients before and after the transfusion. One-way ANOVA was used for the analysis of variance between the weekly ion concentrations and independent sample Mann–Whitney U test for the data obtained from the patients. Results. The mean potassium level of all the samples started with a normal value of 3.45 mmol/L on the first day followed by a sharp rise to 9.40 mmol/L on day 7, 13.40 mmol/L on day 14, 14.60 mmol/L on day 21, and 15.40 mmol/L on day 28. Sodium on the other hand started with a high value of 148.4 mmol/L on day 0 and then reduced to 146.4 mmol/L on day 7, 140.8 mmol/L on day 14, 135.6 mmol/L on day 21, and a low value of 130.8 mmol/L on day 28. No adverse clinical outcomes were seen in patients after they were transfused with the blood. Conclusion. It can be deduced that potassium concentration in refrigerated blood increases, whilst sodium concentration reduces with time and when such blood is transfused, it may not result in any adverse clinical outcome.

更新日期：2019-09-29

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