2-Hydroxy-4-methoxybenzophenone (HMB) is a common ingredient in personal care products and used as an UV stabilizer. In these studies, disposition and metabolism of [14C]HMB in rats and mice was assessed following single gavage administration (10, 100, or 500 mg/kg), single IV administration (10 mg/kg), or dermal application (0.1, 1, 10, or 15 mg/kg).Following gavage administration, [14C]HMB was well absorbed and excreted mainly in urine (39-57%) and feces (24-42%) with no apparent difference between doses, species or sexes. Distribution of HMB in tissues was minimal in rats (0.36%) and mice (<0.55%).Distribution of HMB following dermal application was comparable to that following gavage administration; no differences between doses, sexes, or species were observed but absorption varied between dose vehicles. Light paraffin oil had the highest absorption and excretion (98% of the HMB dose absorbed).In rats, HMB slowly appeared in the systemic circulation (Tmax ∼2-6 h) and had poor bioavailability (F%<1).Urine metabolites for both species and all routes included HMB, HMB-glucuronide, 2,4-dihydroxybenzophenone (DHB), DHB-glucuronide, and DHB-sulfates, and novel minor dihydroxy metabolites including 2,5-dihydroxy-4-methoxybenzophenone.In vitro hepatic metabolism in mice differed from human and in vivo metabolism especially for phase II conjugates.

中文翻译：

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防晒成分2-羟基-4-甲氧基二苯甲酮在Harlan Sprague Dawley大鼠和B6C3F1 / N小鼠中的代谢和分布；物种和路线比较。

2-羟基-4-甲氧基二苯甲酮（HMB）是个人护理产品中的常见成分，并用作紫外线稳定剂。在这些研究中，通过单次强饲法（10、100或500 mg / kg），单次IV给药（10 mg / kg）或经皮肤施用（0.1， 1、10或15 mg / kg）。在管饲法给药后，[14C] HMB被很好地吸收并排泄，主要在尿液（39-57％）和粪便（24-42％）中发生，剂量，种类或剂量之间没有明显差异。性别。在大鼠（0.36％）和小鼠（<0.55％）中，HMB在组织中的分布极少。皮肤施用后HMB的分布与强饲法后相当。没有观察到剂量，性别或种类之间的差异，但是吸收在剂量载体之间变化。