Dammarane triterpenoids are widely distributed in plants and are implicated in various bioactivities and pharmacological effects. This review focuses on advancements in dammarane triterpenoid metabolism, particularly drug design and development, including radiolabeling, absorption, distribution, metabolism, excretion, and pharmacokinetics, which can accurately describe the behaviors of dammarane triterpenoids. This review contributes to the systematic and consistent research and development of dammarane triterpenoids. Their structures and activities, radiolabel application, absorption, distribution, and pharmacokinetic characteristics, possible degradation pathways, metabolic enzyme induction or inhibitory effect, and structure-activity relationships have been described. New intranasal and intra-tympanic administration routes and microdialysis technology have also been introduced. These techniques not only improve the limits of dammarane triterpenoids on absorption and distribution but also facilitate the design and study of these compounds as potential drugs.

中文翻译：

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达玛烷三萜类化合物的药物代谢和药代动力学。


达玛烷三萜类化合物广泛分布于植物中，具有多种生物活性和药理作用。本综述重点关注达玛烷三萜代谢的进展，特别是药物设计和开发，包括放射性标记、吸收、分布、代谢、排泄和药代动力学，可以准确描述达玛烷三萜的行为。该综述有助于达玛烷三萜类化合物的系统、一致的研究和开发。它们的结构和活性、放射性标记的应用、吸收、分布和药代动力学特征、可能的降解途径、代谢酶诱导或抑制作用以及结构-活性关系已经被描述。还引入了新的鼻内和鼓室内给药途径以及微透析技术。这些技术不仅改善了达玛烷三萜类化合物吸收和分布的限制，而且有助于这些化合物作为潜在药物的设计和研究。