<br>裂谷热病毒（布尼亚病毒科：白蛉病毒）：发病机制、分子流行病学、媒介、诊断和预防的最新进展。,Veterinary Research

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裂谷热病毒（布尼亚病毒科：白蛉病毒）：发病机制、分子流行病学、媒介、诊断和预防的最新进展。
Veterinary Research ( IF 3.7 ) Pub Date : 2010-01-01 , DOI: 10.1051/vetres/2010033
Michel Pepin ₁ , Michele Bouloy , Brian H Bird , Alan Kemp , Janusz Paweska

Affiliation

裂谷热 (RVF) 病毒是布尼亚病毒科的一种虫媒病毒，从系统发育分析来看，该病毒似乎首次出现于 19 世纪中叶，直到 20 世纪 30 年代初才在肯尼亚裂谷地区被发现。尽管是一种虫媒病毒，具有相对简单但在时间和地理上稳定的基因组，但这种人畜共患病毒已经表现出在新领域出现的真正能力，埃及（1977年）、西非（1988年）和阿拉伯半岛的爆发就是例证。（2000），或者像最近在肯尼亚和南非观察到的那样，在长期沉寂后重新出现。以前没有裂谷热的国家中存在有效传播媒介、病毒血症动物中的高病毒滴度以及全球气候、旅行和贸易的变化都导致该病毒成为一种不容忽视的威胁，因为裂谷热的后果是巨大的。为了人类和动物的健康。在这篇综述中，我们介绍了裂谷热病毒研究的最新进展。尽管人们重新燃起了兴趣，但裂谷热病毒流行病学的各个方面仍未完全了解，并且仍然无法免费获得安全、有效的疫苗来保护人类和牲畜免受该病毒的严重后果。

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Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention.

Rift Valley fever(RVF) virus is an arbovirus in the Bunyaviridae family that, from phylogenetic analysis, appears to have first emerged in the mid-19th century and was only identified at the beginning of the 1930's in the Rift Valley region of Kenya. Despite being an arbovirus with a relatively simple but temporally and geographically stable genome, this zoonotic virus has already demonstrated a real capacity for emerging in new territories, as exemplified by the outbreaks in Egypt (1977), Western Africa (1988) and the Arabian Peninsula (2000), or for re-emerging after long periods of silence as observed very recently in Kenya and South Africa. The presence of competent vectors in countries previously free of RVF, the high viral titres in viraemic animals and the global changes in climate, travel and trade all contribute to make this virus a threat that must not be neglected as the consequences of RVF are dramatic, both for human and animal health. In this review, we present the latest advances in RVF virus research. In spite of this renewed interest, aspects of the epidemiology of RVF virus are still not fully understood and safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.

更新日期：2019-11-01

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