2-氨基乙基二苯基硼酸盐：一种具有作为药物前体潜力的多靶点化合物。,Current Molecular Pharmacology

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2-氨基乙基二苯基硼酸盐：一种具有作为药物前体潜力的多靶点化合物。
Current Molecular Pharmacology ( IF 2.4 ) Pub Date : 2020-01-01 , DOI: 10.2174/1874467212666191025145429
Melvin N Rosalez ₁ , Elizabeth Estevez-Fregoso ₁ , Alberto Alatorre ₁ , Antonio Abad-García ₁ , Marvin A Soriano-Ursúa ₁

Affiliation

背景技术硼被认为是一种微量元素，可在人体系统中产生各种影响。然而，每种含硼化合物发挥不同的作用。目的回顾有机硼化合物 2-氨基乙基二苯基硼酸酯 (2-APB) 对人体的影响，以及其在人类疾病动物模型中的作用。方法在这篇综述中，已经报道了通过与几个离子通道和其他受体的相互作用来展示这些报告效应扩展的信息。由于将报告的数据应用于开发治疗工具以调节免疫、心血管、胃肠道和神经系统的功能，这些影响与生物医学和化学领域相关。结果因此，2-APB 作为适应性和先天免疫的调节剂，包括细胞因子的产生和白细胞的迁移。此外，报告显示 2-APB 对神经元、平滑肌细胞和心肌细胞产生影响，并通过调节和减弱活性氧提供细胞保护作用。结论 2-APB 的分子药理学支持其作为药物的潜力以及在新药开发中理想地包含其部分。评估其在治疗疼痛和特定疾病（如免疫、心血管、胃肠道和神经退行性疾病）方面的功效的研究很少，但很有趣。它通过调节和减弱活性氧物质来提供细胞保护作用。结论 2-APB 的分子药理学支持其作为药物的潜力以及在新药开发中理想地包含其部分。评估其在治疗疼痛和特定疾病（如免疫、心血管、胃肠道和神经退行性疾病）方面的功效的研究很少，但很有趣。它通过调节和减弱活性氧物质来提供细胞保护作用。结论 2-APB 的分子药理学支持其作为药物的潜力以及在新药开发中理想地包含其部分。评估其在治疗疼痛和特定疾病（如免疫、心血管、胃肠道和神经退行性疾病）方面的功效的研究很少，但很有趣。

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2-Aminoethyldiphenyl Borinate: A Multitarget Compound with Potential as a Drug Precursor.

BACKGROUND Boron is considered a trace element that induces various effects in systems of the human body. However, each boron-containing compound exerts different effects. OBJECTIVE To review the effects of 2-Aminoethyldiphenyl borinate (2-APB), an organoboron compound, on the human body, but also, its effects in animal models of human disease. METHODS In this review, the information to showcase the expansion of these reported effects through interactions with several ion channels and other receptors has been reported. These effects are relevant in the biomedical and chemical fields due to the application of the reported data in developing therapeutic tools to modulate the functions of the immune, cardiovascular, gastrointestinal and nervous systems. RESULTS Accordingly, 2-APB acts as a modulator of adaptive and innate immunity, including the production of cytokines and the migration of leukocytes. Additionally, reports show that 2-APB exerts effects on neurons, smooth muscle cells and cardiomyocytes, and it provides a cytoprotective effect by the modulation and attenuation of reactive oxygen species. CONCLUSION The molecular pharmacology of 2-APB supports both its potential to act as a drug and the desirable inclusion of its moieties in new drug development. Research evaluating its efficacy in treating pain and specific maladies, such as immune, cardiovascular, gastrointestinal and neurodegenerative disorders, is scarce but interesting.

更新日期：2019-11-01

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