Uterine smooth muscle tumors of unknown malignant potential [STUMP]s are neoplasms with pathological features that preclude an equivocal diagnosis of leiomyosarcoma, but that do not fulfill the criteria for leiomyoma or its variants, and raise concerns that the tumors may behave in a malign fashion. Total hysterectomy with or without bilateral salpingo-oophorectomy is the standard treatment if fertility is completed, whereas myomectomy alone can be taken into consideration in young patients who desire to preserve childbearing potential. A careful surveillance every 6 months for 5 years and then yearly is strongly warranted. Patients with STUMP can relapse as either STUMP or leiomyosarcoma in approximately 11-13% of the cases, and their 5-year overall survival ranges from 92 to 100%. The present paper reviews the clinicopathological features of uterine STUMPs with a particular focus on most commonly accepted histopathological criteria for the diagnosis and on biological behaviour of these controversial neoplasms.

中文翻译：

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恶性潜能未知的子宫平滑肌肿瘤：一个具有挑战性的问题。

恶性潜能未知的子宫平滑肌肿瘤是具有病理特征的肿瘤，无法明确诊断平滑肌肉瘤，但不符合平滑肌肉瘤或其变体的标准，并引起人们对肿瘤可能以恶性方式表现的担忧。如果生育力完全，可以进行全子宫切除术，也可以不进行双侧输卵管卵巢切除术，而对于希望保留生育能力的年轻患者，可以单独考虑子宫肌瘤切除术。强烈建议每6个月进行一次仔细监视，持续5年，然后每年进行一次监视。患有STUMP的患者可在约11-13％的病例中复发为STUMP或平滑肌肉肉瘤，其5年总生存率为92％至100％。