KLB基因多态性与汉族人的肥胖和非酒精性脂肪肝有关。,Aging-US

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KLB基因多态性与汉族人的肥胖和非酒精性脂肪肝有关。
Aging-US ( IF 3.9 ) Pub Date : 2019-09-23 , DOI: 10.18632/aging.102293
Fang Ji _{1,

2} , Ye Liu ₃ , Jun-Gui Hao ₂ , Li-Ping Wang ₂ , Ming-Jia Dai ₂ , Gui-Fang Shen ₄ , Xue-Bing Yan _{1,

2}

Affiliation

Klotho beta（KLB）介导成纤维细胞生长因子（FGF）21与FGF受体（FGFR）的结合。FGF21-KLB-FGFR信号调节肝脏中的多个代谢系统，我们假设FGF21，KLB和FGFR单核苷酸多态性（SNP）与肝脂质蓄积有关。在1688个人中检测到SNP，分为四组：非肥胖，无非酒精性脂肪性肝病（NAFLD），肥胖者无NAFLD，非肥胖者NAFLD，肥胖者NAFLD。KLB SNP rs7670903的A等位基因与更高的体重指数相关（P = 0.0005），肥胖者的A等位基因频率高于非肥胖组（P = 0.003）。有NAFLD的肥胖者的KLB rs7674434的G等位基因频率和rs12152703的T等位基因频率高于无NAFLD组的肥胖者（P = 0.004和P = 0.006），但是两个非肥胖人群之间的基因型分布没有差异。在所有受试者中，KLB rs7674434和rs12152703与丙氨酸转氨酶（ALT）（分别为P = 0.03和P = 0.04）和γ-谷氨酰胺基转移酶（分别为P = 0.03和P = 0.02）相关联，但与NAFLD组的ALT（分别为P = 0.005和P = 0.008）。这些发现表明，KLB SNP与肥胖症和肝炎有关，并且可能与NAFLD的发病有关。但在NAFLD组中，与ALT的关联尤其明显（分别为P = 0.005和P = 0.008）。这些发现表明，KLB SNP与肥胖症和肝炎有关，并且可能与NAFLD的发病有关。但在NAFLD组中，与ALT的关联尤其明显（分别为P = 0.005和P = 0.008）。这些发现表明，KLB SNP与肥胖症和肝炎有关，并且可能与NAFLD的发病有关。

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KLB gene polymorphism is associated with obesity and non-alcoholic fatty liver disease in the Han Chinese.

Klotho beta (KLB) mediates binding of fibroblast growth factor (FGF) 21 to the FGF receptor (FGFR). FGF21-KLB-FGFR signaling regulates multiple metabolic systems in the liver, and we hypothesized that FGF21, KLB and FGFR single-nucleotide polymorphisms (SNPs) are involved in hepatic lipid accumulation. The SNPs were detected in 1688 individuals divided into four groups: non-obese without non-alcoholic fatty liver disease (NAFLD), obese without NAFLD, non-obese with NAFLD, and obese with NAFLD. The A-allele of KLB SNP rs7670903 correlated with higher body mass index (P = 0.0005), and the A-allele frequency was higher in the obese than non-obese group (P = 0.003). The G-allele frequency of KLB rs7674434 and T-allele frequency of rs12152703 were higher in the obese with NAFLD than obese without NAFLD group (P = 0.004 and P = 0.006), but the genotype distribution between two non-obese groups did not differ. KLB rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (P = 0.03 and P = 0.04, respectively) and gamma-glutamyltransferase (P = 0.03 and P = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (P = 0.005 and P = 0.008, respectively). These findings suggest that KLB SNPs are related to obesity and hepatic inflammation and that they may be involved in the pathogenesis of NAFLD.

更新日期：2019-11-01

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