映射中风后失语症流利性缺陷的发音和语法子组件。,Cognitive, Affective, & Behavioral Neuroscience

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映射中风后失语症流利性缺陷的发音和语法子组件。
Cognitive, Affective, & Behavioral Neuroscience ( IF 2.5 ) Pub Date : 2019-10-01 , DOI: 10.3758/s13415-019-00729-9
Daniel Mirman _{1,

2,

3} , Amanda E Kraft _{4,

5} , Denise Y Harvey _{3,

6} , Adelyn R Brecher ₃ , Myrna F Schwartz ₃

Affiliation

流利的言语产生是语言处理的一个重要方面，也是失语症诊断和治疗的核心。必须协调多个认知过程和神经子系统才能产生流畅的叙述性语音。为了完善对这些系统的理解，针对发音缺陷和语法缺陷定义了将其他认知过程的影响降至最低的措施。在 115 名左半球中风后失语的参与者中，通过单词重复任务中语音错误（发音和韵律）的比例来衡量发音缺陷。46 名参与者的语法缺陷根据两项指标进行评估 - 封闭类单词的比例和句子中单词的比例 - 在半结构化叙事语音生成（讲述灰姑娘的故事）期间生成。这些措施用于使用基于支持向量回归的多变量病变症状映射方法来识别对语音产生的发音和语法方面至关重要的大脑区域。语音错误比例与中央后回和顶下小叶（特别是缘上回）的损伤有关。叙述性语音中封闭类词的比例没有一致的病变相关。句子中单词的比例与额叶损伤密切相关，尤其是额下回和额中回。语法句子结构依赖于额叶区域，特别是额下回和额中回，而语音发音的规划和执行依赖于顶叶区域，特别是中央后回和边缘上回。

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Mapping articulatory and grammatical subcomponents of fluency deficits in post-stroke aphasia.

Fluent speech production is a critical aspect of language processing and is central to aphasia diagnosis and treatment. Multiple cognitive processes and neural subsystems must be coordinated to produce fluent narrative speech. To refine the understanding of these systems, measures that minimize the influence of other cognitive processes were defined for articulatory deficits and grammatical deficits. Articulatory deficits were measured by the proportion of phonetic errors (articulatory and prosodic) in a word repetition task in 115 participants with aphasia following left hemisphere stroke. Grammatical deficits were assessed in 46 participants based on two measures-proportion of closed class words and proportion of words in sentences-generated during semistructured narrative speech production (telling the Cinderella story). These measures were used to identify brain regions critical for articulatory and grammatical aspects of speech production using a multivariate lesion-symptom mapping approach based on support vector regression. Phonetic error proportion was associated with damage to the postcentral gyrus and the inferior parietal lobule (particularly the supramarginal gyrus). Proportion of closed class words in narrative speech did not have consistent lesion correlates. Proportion of words in sentences was strongly associated with frontal lobe damage, particularly the inferior and middle frontal gyri. Grammatical sentence structuring relies on frontal regions, particularly the inferior and middle frontal gyri, whereas phonetic-articulatory planning and execution relies on parietal regions, particularly the postcentral and supramarginal gyri. These results clarify and extend current understanding of the functional components of the frontoparietal speech production system.

更新日期：2019-11-01

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