增生性白斑患者牙龈上的口腔癌：30例研究。,Journal of Periodontology

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增生性白斑患者牙龈上的口腔癌：30例研究。
Journal of Periodontology ( IF 4.2 ) Pub Date : 2019-05-27 , DOI: 10.1002/jper.18-0620
Jose Bagan ₁ , Judith Murillo-Cortes ₂ , Manuel Leopoldo-Rodado ₃ , Jose M Sanchis-Bielsa ₃ , Leticia Bagan ₄

Affiliation

背景技术增生的疣状白斑，最近被称为增生性白斑（PL），与治疗后复发的强烈趋势和恶性转化率升高相关。我们比较了患有和不进展为口腔鳞状细胞癌的牙龈PL患者的临床特征。方法将患者分为两组：第一组包括33例未进展为癌症的牙龈PL，第二组包括30例在随访过程中发生恶性转化的PL。我们比较了年龄，性别，吸烟习惯，牙龈PL病变的临床特征，部位，肿瘤淋巴结转移（TNM）阶段以及两组之间牙龈恶性肿瘤的临床特征。结果在牙龈癌组中女性占主导地位，与无癌组相比，该组颊粘膜，舌和pa同时受累更为常见。PL病变在癌症患者组中也最大。大多数牙龈癌发生在有牙齿的区域，并以口腔溃疡的形式出现。TNM第一阶段是最常见的。结论PL患者牙龈黏膜同时存在病变，病变扩展程度和溃疡性病变与牙龈癌显着相关。

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Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases.

BACKGROUND Proliferative verrucous leukoplakia, recently coined as proliferative leukoplakia (PL), is associated with a strong tendency to recur after treatment and an elevated rate of malignant transformation. We compared the clinical characteristics of patients with gingival PL with and without progression to oral squamous cell carcinoma. METHODS The patients were divided into two groups: group 1 included 33 patients with gingival PL that did not progress to cancer, and group 2 included 30 patients with PL who developed malignant transformation during follow-up. We compared age, sex, tobacco habit, clinical characteristics of gingival PL lesions, and location, tumor-node-metastasis (TNM) stage, and clinical characteristics of gingival malignancy between groups. RESULTS Female sex was predominant in the group with gingival cancer, and simultaneous involvement of the buccal mucosa, tongue, and palate was more common in this group than in the group without cancer. PL lesions were also largest in the group of patients with cancer. Most gingival cancer occurred in areas with teeth and took the form of oral ulceration. TNM stage I was most common. CONCLUSIONS The simultaneous presence of lesions on the buccal mucosa, grade of lesion extension, and presence of ulcerative lesion were significantly associated with gingival cancer in patients with PL.

更新日期：2019-11-01

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