Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and physiologic processes that were previously inaccessible to imaging. This technique has enabled real-time in vivo investigations of metabolism that are central to a variety of diseases, including cancer, cardiovascular disease, and metabolic diseases of the liver and kidney. This review provides an overview of the methods of hyperpolarization and 13C probes investigated to date in preclinical models of disease. The article then discusses the progress that has been made in translating this technology for clinical investigation. In particular, the potential roles and emerging clinical applications of HP [1-13C]pyruvate MRI will be highlighted. The future directions to enable the adoption of this technology to advance the basic understanding of metabolism, to improve disease diagnosis, and to accelerate treatment assessment are also detailed.

中文翻译：

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超极化13C MRI：最新技术和未来方向。

超极化（HP）碳13（13C）MRI是一种新兴的分子成像方法，可以对以前无法成像的动态代谢和生理过程进行快速，无创且特定于途径的研究。这项技术可以对各种疾病（包括癌症，心血管疾病以及肝脏和肾脏的代谢性疾病）至关重要的新陈代谢进行实时体内研究。这篇综述概述了迄今为止在疾病的临床前模型中研究的超极化方法和13C探针。然后，本文讨论了将该技术用于临床研究的进展。特别要指出的是HP [1-13C]丙酮酸MRI的潜在作用和新兴的临床应用。