CYP2E1：乙醇诱导的肝损伤的生物化学，毒理学，调节作用和功能。,Current Molecular Medicine

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CYP2E1：乙醇诱导的肝损伤的生物化学，毒理学，调节作用和功能。
Current Molecular Medicine ( IF 2.2 ) Pub Date : 2003-10-07 , DOI: 10.2174/1566524033479609
Irina Kessova ₁ , Arthur I Cederbaum

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乙醇诱导的氧化应激似乎在乙醇引起肝损伤的机制中起主要作用。已提出许多途径有助于乙醇诱导氧化应激状态的能力。一个主要途径似乎是乙醇诱导CYP2E1形式的细胞色素P450酶。CYP2E1令人关注，因为它具有代谢和激活许多毒理学底物（包括乙醇）的能力，使其具有更高的反应性和毒性。在各种生理和病理生理条件下以及急性和慢性酒精治疗后，CYP2E1的水平都会升高。CYP2E1还是有效的活性氧生成物，例如超氧阴离子自由基和过氧化氢，在铁催化剂存在下，CYP2E1会产生强力氧化剂，例如羟基自由基。这篇综述文章总结了CYP2E1的一些生化和毒理学特性，并简要介绍了开发用于组成型表达人CYP2E1的HepG2细胞系在评估CYP2E1的作用中的用途。CYP2E1的调节非常复杂，将作简要回顾。将讨论通过抑制CYP2E1或CYP2E1依赖性氧化应激对酒精性肝损伤的治疗可能的治疗意义，并提出一些未来的方向，可能有助于理解CYP2E1的作用及其在酒精性肝损伤中的作用。CYP2E1的调节非常复杂，将作简要回顾。将讨论通过抑制CYP2E1或CYP2E1依赖性氧化应激对酒精性肝损伤的治疗可能的治疗意义，并提出一些未来的方向，可能有助于理解CYP2E1的作用及其在酒精性肝损伤中的作用。CYP2E1的调节非常复杂，将作简要回顾。将讨论通过抑制CYP2E1或CYP2E1依赖性氧化应激对酒精性肝损伤的治疗可能的治疗意义，并提出一些未来的方向，可能有助于理解CYP2E1的作用及其在酒精性肝损伤中的作用。

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CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury.

Ethanol-induced oxidative stress appears to play a major role in mechanisms by which ethanol causes liver injury. Many pathways have been suggested to contribute to the ability of ethanol to induce a state of oxidative stress. One central pathway appears to be the induction of the CYP2E1 form of cytochrome P450 enzymes by ethanol. CYP2E1 is of interest because of its ability to metabolize and activate many toxicological substrates, including ethanol, to more reactive, toxic products. Levels of CYP2E1 are elevated under a variety of physiological and pathophysiological conditions, and after acute and chronic alcohol treatment. CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide, and in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical. This Review Article summarizes some of the biochemical and toxicological properties of CYP2E1, and briefly describes the use of HepG2 cell lines developed to constitutively express the human CYP2E1 in assessing the actions of CYP2E1. Regulation of CYP2E1 is quite complex and will be briefly reviewed. Possible therapeutic implications for treatment of alcoholic liver injury by inhibition of CYP2E1 or CYP2E1-dependent oxidative stress will be discussed, followed by some future directions which may help to understand the actions of CYP2E1 and its role in alcoholic liver injury.

更新日期：2019-11-01

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