2-Aminoimidazole skeleton represents a unique building block which is often used in the design of modulators of different targets and small molecule drugs. Alkaloids isolated from marine sponges are known to be one of the most common sources of the 2-aminoimidazole compounds and from a medicinal chemistry perspective, the marine alkaloids' fascinating structures as well as their broad spectrum of pharmacological activity make them promising lead compounds for various druggable targets. This review will focus on the presentation of biologically evaluated 2-aminoimidazole compounds showing a variety of pharmacological properties and their structure-activity relationship. The importance of 2-aminoimidazoles as bioisosteres of guanidine, acylguanidine, benzamidine and triazole groups will be highlighted.

中文翻译：

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2-氨基咪唑在药物化学中的用途。

2-氨基咪唑骨架代表了独特的构建基块，通常用于设计不同靶标和小分子药物的调节剂。已知从海洋海绵中分离出的生物碱是2-氨基咪唑化合物的最常见来源之一，从药用化学的角度来看，海洋生物碱的引人入胜的结构以及广泛的药理活性使其成为各种应用中有希望的先导化合物可药物化的目标。这篇综述将集中在生物学评估的2-氨基咪唑化合物的呈现上，该化合物显示出多种药理特性及其结构-活性关系。将突出2-氨基咪唑作为胍，酰基胍，苯甲idine和三唑基团的生物等排体的重要性。