离子电渗疗法：电排斥和电渗透。,Journal of Controlled Release

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离子电渗疗法：电排斥和电渗透。
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2000-01-21 , DOI: 10.1016/s0168-3659(99)00132-7
R H Guy ₁ , Y N Kalia , M B Delgado-Charro , V Merino , A López , D Marro

Affiliation

在过去的10到15年中，药物在皮肤上的电增强作用已经得到了广泛的研究。在此期间，已经产生了大量的实验数据，并且成功地增强了各种分子的排列。实际上，可以设想在未来几年内对该方法进行商业开发。尽管取得了这一进展，但是对离子电渗疗法的机械理解仍然是一个具有挑战性的科学问题，尚未完全解决。在施加的电势的影响下的渗透途径，以及转运药物与这些途径的分子相互作用，已经抵抗了明确和明确的鉴定。一样，由于难以设计适当的实验，电排斥和电渗对总离子电渗通量的相对贡献已被证明难以量化。现在已经确定，某些亲脂性阳离子尤其可以在其离子电渗传递过程中与皮肤牢固缔合，从而改变了膜的电性能并改变了输送机理，这一事实使情况进一步复杂化。在这种简短的交流中，已经从简单的理论角度重新考虑了电排斥和电渗的作用，并提出了可以估计其相对重要性的实验方法，并对其进行了初步评估。由于难以设计适当的实验。现在已经确定，某些亲脂性阳离子尤其可以在其离子电渗传递过程中与皮肤牢固缔合，从而改变了膜的电性能并改变了输送机理，这一事实使情况进一步复杂化。在这种简短的交流中，已经从简单的理论角度重新考虑了电排斥和电渗的作用，并提出了可以估计其相对重要性的实验方法并进行了初步评估。由于难以设计适当的实验。现在已经确定，某些亲脂性阳离子尤其可以在其离子电渗传递过程中与皮肤牢固缔合，从而改变了膜的电性能并改变了输送机理，这一事实使情况进一步复杂化。在这种简短的交流中，已经从简单的理论角度重新考虑了电排斥和电渗的作用，并提出了可以估计其相对重要性的实验方法并进行了初步评估。从而改变了膜的电性能，并改变了传输机制。在这种简短的交流中，已经从简单的理论角度重新考虑了电排斥和电渗的作用，并提出了可以估计其相对重要性的实验方法，并对其进行了初步评估。从而改变了膜的电性能，并改变了传输机制。在这种简短的交流中，已经从简单的理论角度重新考虑了电排斥和电渗的作用，并提出了可以估计其相对重要性的实验方法并进行了初步评估。

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Iontophoresis: electrorepulsion and electroosmosis.

Over the last 10-15 years, the electrical enhancement of drug delivery across the skin has undergone intense investigation. During this period, considerable amounts of experimental data have been generated, and the successful enhancement of a diverse array of molecules has been achieved. Indeed, the commercial exploitation of the method can be envisaged within the next few years. Despite this progress, however, the mechanistic understanding of iontophoresis remains a challenging scientific question that is yet to be fully resolved. The routes of permeation under the influence of an applied electrical potential, and the molecular interactions of the transporting drug with these pathways, have resisted unequivocal and unambiguous identification. Equally, the relative contributions of electrorepulsion and electroosmosis to the total iontophoretic flux have proven difficult to quantify, due to the difficulty of designing appropriate experiments. The situation is further complicated by the fact that it has now been established that certain lipophilic cations, in particular, can associate strongly with the skin during their iontophoretic delivery, thereby altering the electrical properties of the membrane, and changing the mechanism of transport. In this short communication, the roles of electrorepulsion and electroosmosis have been reconsidered from a simple theoretical point of view, and experimental approaches by which their relative importance may be estimated have been proposed and subjected to initial evaluation.

更新日期：2019-11-01

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