血清脂蛋白相关磷脂酶A2，缺血性修饰白蛋白与急性冠状动脉综合征之间的关联：一项横断面研究。,Heart and Vessels

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血清脂蛋白相关磷脂酶A2，缺血性修饰白蛋白与急性冠状动脉综合征之间的关联：一项横断面研究。
Heart and Vessels ( IF 1.4 ) Pub Date : 2019-04-08 , DOI: 10.1007/s00380-019-01403-3
Fumeng Yang ₁ , Liping Ma ₁ , Lili Zhang ₂ , Yilian Wang ₃ , Changxin Zhao ₁ , Wenjun Zhu ₁ , Wei Liang ₁ , Qian Liu ₁

Affiliation

脂蛋白相关的磷脂酶A2（Lp-PLA2）是一种新兴的生物标志物，具有很强的促炎作用，并且是动脉粥样硬化斑块破裂和血栓形成的独立风险预测因子。另外，缺血修饰的白蛋白（IMA）是评估心肌缺血的另一个重要标志，并已获得美国食品和药物管理局（US Food and Drug Administration）的批准。这项研究的目的是调查血清Lp-PLA2和IMA在急性冠状动脉综合征（ACS）的早期诊断，进展和预后中的作用。使用AU5800自动生化分析仪在180例ACS患者中检出血清Lp-PLA2和IMA [n = 60，不稳定型心绞痛（UA），n = 56，非ST段抬高型心肌梗死（NSTEMI），ST段抬高型心肌梗死（STEMI）的n = 64]和60名健康对照组。探讨了Lp-PLA2和IMA与Gensini评分和冠状动脉病变数目之间的关系，并进行了逻辑回归分析以识别重大心血管不良事件（MACE）的危险因素。在所有ACS亚组中，血清Lp-PLA2和IMA均显着高于对照组（P <0.05），基于Gensini评分与ACS严重程度呈正相关（P <0.05），而在ACS患者中则显着更高与单支血管病变和健康对照组相比，双支和三支血管病变（P <0.05）。Logistic回归确定Lp-PLA2，IMA和肌钙蛋白I水平是MACE的独立危险因素。

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Association between serum lipoprotein-associated phospholipase A2, ischemic modified albumin and acute coronary syndrome: a cross-sectional study.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a newly emerging biomarker with strong pro-inflammatory effects, and is an independent risk predictor of atherosclerotic plaque rupture and thrombosis. In addition, ischemic modified albumin (IMA) is another important marker for the evaluation of myocardial ischemia, and has been approved by the U.S. Food and Drug Administration. The objective of this study was to investigate serum Lp-PLA2 and IMA in the early diagnosis, progression and prognosis of acute coronary syndrome (ACS). Serum Lp-PLA2 and IMA were detected using an AU5800 automatic biochemical analyzer in samples from 180 patients with ACS [n = 60 with unstable angina pectoris (UA), n = 56 with non-ST segment elevation myocardial infarction (NSTEMI), and n = 64 with ST segment elevation myocardial infarction (STEMI)] and 60 healthy control subjects. The relationship between Lp-PLA2 and IMA with Gensini score and the number of coronary artery lesions was explored, and logistic regression was conducted to identify risk factors for major adverse cardiovascular events (MACE). Serum Lp-PLA2 and IMA were significantly higher in all ACS subgroups compared to the control group (P < 0.05), were positively associated with the severity of ACS based on the Gensini score (P < 0.05), and were significantly higher in patients with double- and triple-vessel lesions compared to those with single-vessel lesions and healthy controls (P < 0.05). Logistic regression identified Lp-PLA2, IMA, and troponin I levels as independent risk factors for MACE. Lp-PLA2 and IMA were predictive of the degree of myocardial ischemia in patients with ACS, and may provide important clinical significance for the early diagnosis of ACS and the choice of treatment strategy.

更新日期：2019-11-01

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