BACKGROUND The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing. OBJECTIVES To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy. METHODS A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate. RESULTS Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001). CONCLUSIONS The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.

中文翻译：

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用羊毛脂酒精和Amerchol L101诊断羊毛脂接触过敏。

背景技术在皮炎患者中，羊毛脂接触过敏的患病率从1.2％到6.9％不等。在贴剂测试中使用了不同的羊毛脂衍生物。目的确定哪种羊毛脂衍生物的组合在斑贴测试中最有效地诊断羊毛脂接触过敏。方法对2016年至2017年间测试的患者斑块进行回顾性分析。如果患者接受过30％的羊毛脂酒精，50％的Amerchol L101以及包含其他羊毛脂衍生物的补充产品系列的测试，则符合资格。重复测试羊毛脂醇和Amerchol L101。结果在594例患者中，有28.6％（95％的置信区间[CI]：25.1％-32.3％）的至少一种羊毛脂衍生物的斑贴试验反应阳性。与羊毛脂醇（14.7％，95％CI：11.3％-18.2％）和Amerchol L101（15.0％，95％CI：11.5％-18.5％）在常规测试系列中很常见。与其他测试制剂的反应发生频率显着降低（P <0.05）。将Amerchol L101加入羊毛脂酒精中可显着增加阳性病例的数量（比值1.79，P <0.001）。结论羊毛脂酒精和Amerchol L101的组合可有效用于补丁测试，以诊断羊毛脂接触过敏。用其他羊毛脂衍生物进行常规测试可能不值得，因为它只能检测出少数几例患者。结论羊毛脂酒精和Amerchol L101的组合可有效地用于补丁测试，以诊断羊毛脂接触过敏。用其他羊毛脂衍生物进行常规测试可能不值得，因为它只能检测出少数几例患者。结论羊毛脂酒精和Amerchol L101的组合可有效用于补丁测试，以诊断羊毛脂接触过敏。用其他羊毛脂衍生物进行常规测试可能不值得，因为它只能检测出少数几例患者。