Imidazo[1,2-a]pyridine is one of the most potential bicyclic 5-6 heterocyclic rings that is recognized as a "drug prejudice" scaffold due to its broad range of applications in medicinal chemistry such as anticancer, antimycobacterial, antileishmanial, anticonvulsant, antimicrobial, antiviral, antidiabetic, proton pump inhibitor, insecticidal activities. This scaffold has also been represented in various marketed preparations such as zolimidine, zolpidem, alpidem. Therefore, several attempts were made to carry out the structural modifications of this scaffold to discover and develop novel therapeutic agents. This review provides a valuable insight into the research findings of wide range of derivatives of imidazo[1,2-a]pyridine scaffold leading to promising heterocyclic compounds which could be explored further for the synthesis of new derivatives as well as construction of potential drug-like chemical libraries for biological screening in search of new therapeutic agents.

中文翻译：

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咪唑并[1,2-a]吡啶骨架作为预期的治疗药物。

咪唑并[1,2-a]吡啶是最有潜力的双环5-6杂环之一，由于其在药物化学领域的广泛应用，例如抗癌，抗分枝杆菌，抗真菌，抗惊厥，被公认为“药物偏见”支架，抗菌，抗病毒，抗糖尿病，质子泵抑制剂，杀虫活性。该支架也已经在各种市售制剂中得到了代表，例如佐利米定，唑吡坦，阿吡培姆。因此，进行了数种尝试以对该支架进行结构修饰以发现和开发新的治疗剂。这篇综述为对咪唑类衍生物的广泛研究结果提供了宝贵的见解[1，