A modified convenient and high yielding synthetic route for the preparation of the dopamine agonist roxindole 1 is described. The key step in our method is the phase-transfer catalyzed reaction of gamma-butyrolactone with 5-methoxyindole which results in the indolylbutyric acid derivative directly in one step.

中文翻译：

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一种合成多巴胺D2受体激动剂roxindole的简单程序。

描述了用于制备多巴胺激动剂roxindole 1的改进的方便且高产率的合成途径。我们方法的关键步骤是γ-丁内酯与5-甲氧基吲哚的相转移催化反应，一步即可直接生成吲哚基丁酸衍生物。