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Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.
Natural Product Research ( IF 1.9 ) Pub Date : 2018-02-19 , DOI: 10.1080/14786419.2018.1434645 Wenxiang Wang 1 , Xilatu Dabu 2 , Juan He 3 , Huixiang Yang 3 , Shengchao Yang 1 , Junwen Chen 1 , Wei Fan 1, 2 , Guanghui Zhang 1 , Jinlong Cai 1 , Honglian Ai 3 , Meirong Hai 1
中文翻译:
玉竹H,一种新的具有细胞毒性的高异黄酮,来自玉竹。
更新日期:2018-02-19
Natural Product Research ( IF 1.9 ) Pub Date : 2018-02-19 , DOI: 10.1080/14786419.2018.1434645 Wenxiang Wang 1 , Xilatu Dabu 2 , Juan He 3 , Huixiang Yang 3 , Shengchao Yang 1 , Junwen Chen 1 , Wei Fan 1, 2 , Guanghui Zhang 1 , Jinlong Cai 1 , Honglian Ai 3 , Meirong Hai 1
Affiliation
A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2–15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin.
中文翻译:
玉竹H,一种新的具有细胞毒性的高异黄酮,来自玉竹。
除十四个以外,新的同型异黄酮,(3 R)-5,7-二羟基-6-甲基-3-(2'-羟基-4'-甲氧基苄基)-苯并-4-酮(1)已知homoisoflavones(2 - 15)从的根茎中分离玉竹黄精华。借助1D / 2D NMR光谱技术鉴定了结构。化合物2,6,8,10,11,13,和15从分离P.黄精首次。化合物1通过IC对人癌细胞系显示出细胞毒性相当于顺铂的50个值。