Verrucofortine [8], an alkaloid derived from tryptophan and leucine, has been isolated from the fungus Penicillium verrucosum var. cyclopium. The structure and absolute configuration have been established by a combination of spectroscopic and chemical techniques. Its structure is unrelated to that of other major metabolite of the organism, the highly toxic pyrone-type polyketide verrucosidin [1], which was previously reported to be a tremorgen. A second novel metabolite, normethylverrucosidin [3], has also been isolated and identified. Small quantities of several other secondary metabolites, ergosterol, cyclopenin [4], cyclopenol [5], and 3-O-methylviridicatin [6], were isolated. They are known fungal metabolites but had not previously been obtained from this fungus. Studies of verrucofortine toxicity in mice showed no apparent toxic effects at doses as high at 160 mg/kg ip.

中文翻译：

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Verrucofortine，青霉青霉的主要代谢产物。Cyclopium，产生霉菌毒素Verrucosidin的真菌。

Verrucofortine [8]是一种从色氨酸和亮氨酸衍生的生物碱，已从真菌Penicillium v​​errucosum var中分离出来。cyclopium。通过光谱学和化学技术的结合已经确定了结构和绝对构型。它的结构与生物的其他主要代谢产物高毒性的吡喃酮型聚酮类维可考定[1]无关，后者以前曾被报道为震颤剂。第二种新的代谢产物，正甲基verrucosidin [3]，也已被分离和鉴定。分离了少量其他几种次生代谢物，麦角固醇，环penin [4]，cyclopenol [5]和3-O-甲基viridicatin [6]。它们是已知的真菌代谢物，但以前从未从这种真菌中获得。