Synthesis and pharmacological characterisation of a series of products obtained by coupling the H(3)-antagonist SKF 91486 through appropriate spacers with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan substructures, devoid of NO-donating properties, are reported. All the products were tested for their H(3)-antagonistic and H(2)-agonistic properties on electrically-stimulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. The whole series of compounds displayed good H(3)-antagonist behaviour and feeble partial H(2)-agonist activity. Among furoxan derivatives, the benzenesulfonyl hybrid 28, a good NO-donor, triggered a dual NO-dependent muscle relaxation and H(3)-antagonistic effect on guinea-pig intestine.

中文翻译：

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含有呋喃喃部分的[3-（1H-咪唑-4-基）丙基]胍：具有NO-给体性质的新型H3-拮抗剂。

H（3）-拮抗剂SKF 91486通过合适的间隔基与NO供体3-苯基呋喃喃-4-基氧基和3-苯磺酰基呋喃喃-4-基氧基部分以及与据报道，相应的呋喃山亚结构没有提供NO的特性。测试了所有产品在电刺激的豚鼠回肠段和豚鼠乳头肌上的H（3）-拮抗和H（2）-激动特性。整个系列的化合物显示良好的H（3）-拮抗剂行为和微弱的部分H（2）-激动剂活性。在呋喃喃衍生物中，苯磺酰基杂化物28，一个好的NO供体，引发了对豚鼠肠道的双重NO依赖性肌肉松弛和H（3）-拮抗作用。