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Aristolochic acids, aristolactam alkaloids and amides from Aristolochia kankauensis
Phytochemistry ( IF 3.2 ) Pub Date : 1994-07-01 , DOI: 10.1016/s0031-9422(00)90492-8
Wu Tian-Shung , Ou Li-Fei , Teng Che-Ming

Fourteen aristolochic acid derivatives: ariskanins A-E, 3-hydroxy-4-methoxy-10-nitrophenanthrene-1-carboxylic acid methyl ester, aristolochic acid-II methyl ester, aristolochic acid-IV methyl ester, aristolochic acid-C, -I, -II, -III, -IV, -IVa; nine aristolactam alkaloids: aristolactam, aristolactam-AII, -BIII, -AIII, -III, cepharanone-A, 9-methoxy-aristolactam-I, aristolactam-N-beta-D-glucoside and aristolactam-C-N-beta-D-glucoside; a 4,5-dioxoaporphine alkaloid: cepharadione-A, together with 12 other compounds: methyl-p-coumarate, N-trans-feruloyltyramine, N-cis-feruloyltyramine, methyl vanillate, methyl paraben, allantoin, an octadecyl- and eicosyl ferulate mixture, cis- and trans-p-coumaric acid, N-p-coumaroyltyramine, N-p-cis-coumaroyltyramine, methyl ferulate and isorhamnetin-3-O-rutinoside were isolated and characterized from the fresh root and stem of Aristolochia kankauensis. Their structures were elucidated by spectral and chemical methods. Among them, ariskanins-A-E and N-p-cis-coumaroyltyramine are reported for the first time from a natural source. The cytotoxicity and antiplatelet activity of the compounds isolated are also discussed.

中文翻译:

来自马兜铃属植物的马兜铃酸、马兜铃内酰胺生物碱和酰胺

十四种马兜铃酸衍生物:马兜铃素AE、3-羟基-4-甲氧基-10-硝基菲-1-羧酸甲酯、马兜铃酸-II甲酯、马兜铃酸-IV甲酯、马兜铃酸-C、-I、- II、-III、-IV、-IVa;九种马兜铃生物碱:马兜铃内酰胺、马兜铃内酰胺-AII、-BIII、-AIII、-III、头孢菌酮-A、9-甲氧基-马里内酰胺-I、马兜铃内酰胺-N-β-D-葡萄糖苷和马兜铃内酰胺-CN-β-D-葡萄糖苷; 4,5-二氧代阿帕啡生物碱:头孢拉定-A,以及其他 12 种化合物:对香豆酸甲酯、N-反式阿魏酰苯胺、N-顺式-阿魏酰苯胺、香草酸甲酯、对羟基苯甲酸甲酯、尿囊素、十八烷基阿魏酸和二十烷基阿魏酸混合物,顺式和反式对香豆酸,Np-香豆酰酪胺,Np-顺式-香豆酰酪胺,从甘高马兜铃的新鲜根和茎中分离并表征了阿魏酸甲酯和异鼠李素-3-O-芸香苷。通过光谱和化学方法阐明了它们的结构。其中,ariskanins-AE和Np-cis-coumaroyltyramine是首次从天然来源报道。还讨论了分离的化合物的细胞毒性和抗血小板活性。
更新日期:1994-07-01
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