OBJECTIVES To explore the prognostic and discriminatory ability of the AJCC 8th Edition Oral Cavity cancer staging in a non-North American population, and compare it to the previously used AJCC 7th Edition. MATERIALS AND METHODS Retrospective chart review was performed at a tertiary referral Otolaryngology, Head Neck and Skull Base Department in Australia, from June 2002 to June 2017. Oral cavity squamous cell carcinoma cases were staged according to AJCC 8th Edition, which was compared to AJCC 7th Edition staging, for disease-free survival (DFS) and overall survival (OS). DFS and OS were analysed using Kaplan-Meier curves. RESULTS There were 118 patients treated for OSCC, with an average age of 61 years, 63% were male. Overall survival grouped by stage demonstrated statistically significant discrimination between cancer stages using both the AJCC 7th and AJCC 8th Editions. AJCC 7th Edition did not discriminate between stages for DFS. Conversely, AJCC 8th Edition did statistically significantly discriminate for DFS (p = 0.0002). The DFS for both Stage 4a and 4b was significantly worse than cases in Stage 1. AJCC 8th Edition T stage was statistically significantly related to DFS (p = 0.0199), while the AJCC 7th Edition T stage was not. CONCLUSION The AJCC Cancer Staging Manual 8th Edition includes both the depth of primary tumour invasion and extracapsular extension of lymph node metastases. The AJCC 8th Edition OSCC staging system showed improved disease-free survival discrimination between overall stages and between T categories, while AJCC 7th Edition did not.

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AJCC第八版口腔鳞状细胞癌分期-是对AJCC第七版的改进吗？

目的探讨非北美人群中AJCC第8版口腔腔癌分期的预后和区分能力，并将其与以前使用的AJCC第7版进行比较。材料与方法回顾性图表回顾于2002年6月至2017年6月在澳大利亚头颈和颅底基底科的第三级转诊耳鼻咽喉科进行。口腔鳞状细胞癌病例根据AJCC第8版进行分期，与AJCC第7版进行比较版本分期，用于无病生存期（DFS）和总体生存期（OS）。使用Kaplan-Meier曲线分析了DFS和OS。结果OSCC患者118例，平均年龄61岁，男性63％。使用AJCC第7版和AJCC第8版，按阶段分组的总体生存率在癌症阶段之间显示出统计学上的显着区别。AJCC第7版没有区分DFS的各个阶段。相反，AJCC第8版确实对DFS进行了统计学上的区分（p = 0.0002）。阶段4a和4b的DFS均显着低于阶段1的病例。AJCC第八版T阶段与DFS有统计学意义（p = 0.0199），而AJCC第七版T阶段则没有。结论《 AJCC癌症分期手册》第8版包括原发肿瘤的浸润深度和淋巴结转移的囊外延伸。AJCC第8版OSCC分期系统显示出总体阶段之间以及T类之间的无病生存区分得到改善，而AJCC第7版则没有。