醛糖酮还原酶超家族主页。,Chemico-Biological Interactions

当前位置： X-MOL 学术 › Chem. Biol. Interact. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

醛糖酮还原酶超家族主页。
Chemico-Biological Interactions ( IF 4.7 ) Pub Date : 2003-02-27 , DOI: 10.1016/s0009-2797(02)00193-x
David Hyndman ₁ , David R Bauman , Vladi V Heredia , Trevor M Penning

Affiliation

醛酮还原酶（AKRs）是对多种天然和外来底物进行氧化还原的三种酶超家族之一。AKR超家族的系统命名法于1996年采用，并于2000年9月进行了更新（请访问www.med.upenn.edu/akr）。研究人员一直在努力向网站提交功能蛋白序列。通过添加新成员，该超家族包含114个原核生物和真核生物中表达的蛋白质，分布在14个家族中（AKR1-AKR14）。AKR1家族包含醛糖还原酶，醛还原酶，羟类固醇脱氢酶和类固醇5β还原酶，并且是最大的。其他感兴趣的家族包括AKR6（其包含钾通道β亚基）和AKR7（黄曲霉毒素醛还原酶）。两个新家族包括AKR13（酵母醛糖还原酶）和AKR14（大肠杆菌醛还原酶）。许多AKR的晶体结构及其与配体的配合物可在PDB中获得，并可通过网站访问。每个结构具有超家族的特征性（alpha / beta）（8）-桶基序，保守的辅因子结合位点和催化四联体以及定义底物特异性的可变环结构。尽管大多数AKR是长度约为320个氨基酸的单体蛋白，但AKR2，AKR6和AKR7家族可形成多聚体。为了扩展命名法以适应多聚体，我们建议列出组成和化学计量。例如，AKR7A1：AKR7A4（1：3）表示所示组成的四聚体。

"点击查看英文标题和摘要"

The aldo-keto reductase superfamily homepage.

The aldo-keto reductases (AKRs) are one of the three enzyme superfamilies that perform oxidoreduction on a wide variety of natural and foreign substrates. A systematic nomenclature for the AKR superfamily was adopted in 1996 and was updated in September 2000 (visit www.med.upenn.edu/akr). Investigators have been diligent in submitting sequences of functional proteins to the Web site. With the new additions, the superfamily contains 114 proteins expressed in prokaryotes and eukaryotes that are distributed over 14 families (AKR1-AKR14). The AKR1 family contains the aldose reductases, the aldehyde reductases, the hydroxysteroid dehydrogenases and steroid 5beta-reductases, and is the largest. Other families of interest include AKR6, which includes potassium channel beta-subunits, and AKR7 the aflatoxin aldehyde reductases. Two new families include AKR13 (yeast aldose reductase) and AKR14 (Escherichia coli aldehyde reductase). Crystal structures of many AKRs and their complexes with ligands are available in the PDB and accessible through the Web site. Each structure has the characteristic (alpha/beta)(8)-barrel motif of the superfamily, a conserved cofactor binding site and a catalytic tetrad, and variable loop structures that define substrate specificity. Although the majority of AKRs are monomeric proteins of about 320 amino acids in length, the AKR2, AKR6 and AKR7 family may form multimers. To expand the nomenclature to accommodate multimers, we recommend that the composition and stoichiometry be listed. For example, AKR7A1:AKR7A4 (1:3) would designate a tetramer of the composition indicated. The current nomenclature is recognized by the Human Genome Project (HUGO) and the Web site provides a link to genomic information including chromosomal localization, gene boundaries, human ESTs and SNPs and much more.

更新日期：2019-11-01

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南