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The Use of Hydrazones for Biomedical Applications.
SLAS Technology: Translating Life Sciences Innovation ( IF 2.5 ) Pub Date : 2019-02-13 , DOI: 10.1177/2472630318822713
Jenna Wahbeh 1 , Sarah Milkowski 1
Affiliation  

The use of hydrazones presents an opportunity for enhancing drug delivery through site-specific drug release, including areas such as tumor tissue or thrombosis. Many researchers are experimenting on how to more efficiently form these hydrazones, specifically using heat and chemical catalysts. Hydrazones respond on the pH environment or are synthesized with particular functional groups of the hydrazone and are two of the many unique features that allow for their programmed drug release. Their flexibility allows them to be relevant in a diverse range of applications, from anti-inflammatory to anticancer to acting as a chelating agent. This review paper discusses efficient ways to optimize the properties of hydrazones and their utilization in various clinical applications, including anticancer, anti-inflammatory, the prevention of platelet aggregation, and roles as chelating agents.

中文翻译:

Hy在生物医学中的应用。

的使用为通过位点特异性药物释放(包括诸如肿瘤组织或血栓形成的区域)释放药物提供了机会。许多研究人员正在研究如何更有效地形成这些,特别是使用加热和化学催化剂。dra可在pH环境中反应或与with的特定官能团合成,并且是许多使其程序化药物释放的独特特征中的两个。它们的柔韧性使它们在从消炎到抗癌再到作为螯合剂的各种应用中具有重要意义。这篇综述文章讨论了优化的性质及其在各种临床应用中的利用的有效方法,包括抗癌,抗炎,
更新日期:2019-11-01
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