Copolymers of N-(2-hydroxypropyl)methacrylamide which contained up to 20 mol % of p-nitrophenyl esters of N-methacryloylated oligopeptides, and of N-methacryloylaminophenoxyacetic acids (o-, m-, p-) have been prepared. The aminolyses of these polymers with tert. butylamine, ampicillin and 6-aminopenicillanic acid were kinetically characterized. Based on these results polymer bound ampicillin and polymer bound 6-aminopenicillanic acid were prepared. These preparations possessed antimicrobial activity; they inhibited the growth of Staphylococcus aureus 209 P.

中文翻译：

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具有抗菌活性的N-（2-羟丙基）甲基丙烯酰胺共聚物的合成。

制备了N-（2-羟丙基）甲基丙烯酰胺和N-甲基丙烯酰氨基苯氧基乙酸（o-，m-，p-）的共聚物，所述共聚物包含高达20mol％的N-甲基丙烯酰化的寡肽的对硝基苯基酯。这些聚合物具有叔胺基。动力学表征了丁胺，氨苄青霉素和6-氨基青霉烯酸。基于这些结果，制备了聚合物结合的氨苄青霉素和聚合物结合的6-氨基青霉酸。这些制剂具有抗菌活性。它们抑制了金黄色葡萄球菌209 P的生长。