木槿Sabdariffa Calyces水提取物对二肾一夹大鼠高血压模型中卡托普利的降压效力。,Evidence-based Complementary and Alternative Medicine

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木槿Sabdariffa Calyces水提取物对二肾一夹大鼠高血压模型中卡托普利的降压效力。
Evidence-based Complementary and Alternative Medicine Pub Date : 2019-07-17 , DOI: 10.1155/2019/9694212
Shinta Ayu Nurfaradilla ₁ , Fadlina Chany Saputri ₂ , Yahdiana Harahap ₃

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芙蓉水提取物（HS）通常用作高血压的辅助疗法。但是，一些研究表明与常规降压药合用会影响药效。我们比较了高血压加大鼠双肾一夹（2K1C）模型中HS加卡托普利（CAP）共同给药与单纯HS和CAP给药对血压和肾素-血管紧张素-醛固酮系统（RAAS）生物标志物的影响。将雄性Sprague Dawley大鼠随机分为7组（n = 6 /组），正常对照组（SHAM）和6个2K1C组。在2K1C动物中，使用不锈钢微夹（内径为0.20毫米）诱发了高血压。2K1C手术后四周，血压显着高于SHAM组。然后，将模型大鼠随机分为阴性对照（2K1C，未治疗），阳性对照（4.5 mg卡托普利/ 200 g体重[口服] [po]），单纯HS（30 mg / 200 g BW；口服）和3个接受HS的联合治疗组（15、30或60 mg / 200 g BW; po）加4.5 mg / 200 g BW卡托普利。治疗进行了两个星期。所有药物治疗均使血压显着降低至SHAM对照水平。与SHAM组相比，2K1C组的血浆肾素水平，血清血管紧张素转化酶（ACE）活性和血浆血管紧张素II水平也显着升高。通过所有药物治疗，血清ACE活性和血浆血管紧张素II水平均显着降低至SHAM组水平。5 mg / 200 g BW卡托普利。治疗进行了两个星期。所有药物治疗均使血压显着降低至接近SHAM对照水平。与SHAM组相比，2K1C组的血浆肾素水平，血清血管紧张素转化酶（ACE）活性和血浆血管紧张素II水平也显着升高。通过所有药物治疗，血清ACE活性和血浆血管紧张素II水平均显着降低至SHAM组水平。5 mg / 200 g BW卡托普利。治疗进行了两个星期。所有药物治疗均使血压显着降低至SHAM对照水平。与SHAM组相比，2K1C组的血浆肾素水平，血清血管紧张素转化酶（ACE）活性和血浆血管紧张素II水平也显着升高。通过所有药物治疗，血清ACE活性和血浆血管紧张素II水平均显着降低至SHAM组水平。芙蓉水提取物可以单独降低血压。这种提取物似乎可以用作卡托普利的补充剂，但可能不会提供任何其他好处。

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Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model.

Hibiscus sabdariffa aqueous extract (HS) is often used as complementary therapy for hypertension. However, some studies have shown that coadministration with a conventional antihypertensive drug can affect drug potency. We compared the effects of HS plus captopril (CAP) coadministration to HS and CAP administration alone on blood pressure and renin-angiotensin-aldosterone system (RAAS) biomarkers in the rat two-kidney-one-clip (2K1C) model of hypertension. Male Sprague Dawley rats were randomly divided into seven groups (n=6/group), a normal control (SHAM) group, and six 2K1C groups. In 2K1C animals, hypertension was induced using a stainless microclip (inner diameter of 0.20 mm). Four weeks after 2K1C surgery, blood pressure was significantly higher than in the SHAM group. Then, model rats were randomly divided into negative control (2K1C, no treatment), positive control (4.5 mg captopril/200 g body weight [BW] orally [p.o.]), HS alone (30 mg/200 g BW; p.o.), and 3 co-treatment groups receiving HS (15, 30, or 60 mg/200 g BW; p.o.) plus 4.5 mg/200 g BW captopril. The treatments were performed for two weeks. Blood pressure was significantly reduced by all the drug treatments to near the level of SHAM controls. Plasma renin level, serum angiotensin converting enzyme (ACE) activity, and plasma angiotensin II level were also significantly elevated in the 2K1C group compared to the SHAM group. Both serum ACE activity and plasma angiotensin II level were significantly reduced to near SHAM group levels by all the drug treatments. Hibiscus sabdariffa aqueous extract alone can reduce blood pressure. This extract appears could be used as a supplement with captopril but may not provide any additional benefit.

更新日期：2019-07-17

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