Background: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents.

Objective: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness.

Method: Thorough literature review of all relevant papers and patents was conducted.

Conclusion: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

背景：咪唑并[2,1-b]噻唑，一种著名的稠合五元杂环，是药物化学领域最有前途和用途最广泛的部分之一。已对咪唑并[2,1-b]噻唑的衍生物进行了研究，以开发具有多种药理活性的新衍生物。该稠合的杂环也是许多治疗剂的一部分。

目的：综述咪唑并[2,1-b]噻唑衍生物及其在2000-2018年间开发的新分子的广泛药理活性及其实用性。

方法：对所有相关论文和专利进行了详尽的文献综述。

结论：本综述涵盖了多个方面，有望为基于咪唑并[2,1-b]噻唑的化合物的设计提供有用的见识，并会激发药物化学家获得全面且面向目标的信息，以实现这一目标。在临床上可行的候选药物开发方面的重大突破。