实施局部麻醉：当前策略，安全性和未来前景。,Current Drug Metabolism

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实施局部麻醉：当前策略，安全性和未来前景。
Current Drug Metabolism ( IF 2.1 ) Pub Date : 2019-01-01 , DOI: 10.2174/1389200220666190610155049
Guo-Liang Liu ₁ , Wen-Chao Bian ₂ , Peng Zhao ₁ , Li-Hua Sun ₁

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背景技术全身麻醉与严重和不良副作用有关，例如镇静，呕吐，恶心，过敏，呼吸问题和中性粒细胞功能障碍。随着肢体手术，美容，面部，皮肤和癌症重建手术的增加，在过去的十年中，局部麻醉的需求增加了两倍。因此，正在开发新颖，安全且具有成本效益的方法来由外科医生进行局部麻醉。方法为了准备一份有关麻醉的综合研究报告，我们对书目数据库进行了结构化文献检索，以查找最近发表的同行评审文章。总结了不同文章的研究，并进行了定性和定量数据分析。后来，分析的全面摘要用于为这篇评论文章提供充足的示例。结果对报告的透彻分析表明，合成基于纳米颗粒的局麻药已取得了巨大进展。基于纳米颗粒的药物递送策略的主动靶向能力可以进一步帮助局部递送所需的麻醉药。还发现，不同的局部麻醉药发展为脂质体形式，并且在接受麻醉的患者中显示出更好的功效。结论这篇综述性文章的结论支持麻醉药物的安全输送对于患者的安全至关重要。此外，基于纳米技术的策略对于以所需剂量靶向递送麻醉药物而不影响邻近组织非常有用。

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Delivery of Local Anesthesia: Current Strategies, Safety, and Future Prospects.

BACKGROUND The systemic administration of anesthesia is associated with severe and undesirable side effects such as sedation, vomiting, nausea, allergies, respiratory problems, and neutrophil dysfunction. With the increase in the procedures of limb surgery, cosmetics, facial, skin, and cancer reconstruction, the demand for local anesthesia has increased multifold during the last one decade. Therefore, novel, safe, and cost-effective methods are being developed to deliver local anesthetics by the surgeons. METHOD To prepare a comprehensive research report on anesthesia, we performed a structured literature search of bibliographic databases for peer-reviewed articles published recently. The studies of different articles were summarized and a deductive qualitative and quantitative data analysis was applied. Subsequently, a comprehensive summary of the analysis was used to frame this review article with ample examples. RESULTS A thorough analysis of the reports suggested that there have been tremendous developments of synthesizing nanoparticle-based local anesthesia drugs. The active targeting ability of nanoparticle-based drug delivery strategy can further help to deliver the desired anesthetic drug locally. It was also found that different local anesthetic drugs are developed into liposome form and show better efficacy in patients receiving anesthesia. CONCLUSION The findings of this review article endorse that safe delivery of anesthesia drugs are essential for the safety of patients. Further, nanotechnology-based strategies are extremely useful for targeted delivery of anesthetic drugs at the required dose without affecting the neighboring tissues.

更新日期：2019-11-01

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