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Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 1979-02-01 , DOI: 10.7164/antibiotics.32.100 JOHN W. WESTLEY , RALPH H. EVANS Jr. , LILIAN H. SELLO , NELSON TROUPE
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 1979-02-01 , DOI: 10.7164/antibiotics.32.100 JOHN W. WESTLEY , RALPH H. EVANS Jr. , LILIAN H. SELLO , NELSON TROUPE
A novel carboxylic acid ionophore, antibiotic X-14547A, closely related to the polyether antibiotics has been isolated along with four other metabolites from fermented cultures of a new strain of Streptomyces antibioticus. The structure, determined by X-ray analysis of the R(+)-1-amino-1-(4-bromophenyl)-ethane salt contained pyrrole carbonyl and trans-butadienyl chromophores in addition to the unusual tetrahydroindane bicyclic ring system. A second novel metabolite was identified as 3-ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one.
中文翻译:
抗生素X-14547A的分离和表征,这是一种由链霉菌NRRL 8167生产的新型单羧酸离子载体。
从新的链霉菌菌株的发酵培养物中分离出了一种与聚醚抗生素密切相关的新型羧酸离子载体抗生素X-14547A。通过X射线分析R(+)-1-氨基-1-(4-溴苯基)-乙烷盐确定的结构,除了不寻常的四氢茚满双环体系外,还包含吡咯羰基和反丁二烯发色团。第二种新的代谢产物被鉴定为3-乙基-1,3-二氢-3-甲氧基-2H-吲哚-2-酮。
更新日期:2019-11-01
中文翻译:
抗生素X-14547A的分离和表征,这是一种由链霉菌NRRL 8167生产的新型单羧酸离子载体。
从新的链霉菌菌株的发酵培养物中分离出了一种与聚醚抗生素密切相关的新型羧酸离子载体抗生素X-14547A。通过X射线分析R(+)-1-氨基-1-(4-溴苯基)-乙烷盐确定的结构,除了不寻常的四氢茚满双环体系外,还包含吡咯羰基和反丁二烯发色团。第二种新的代谢产物被鉴定为3-乙基-1,3-二氢-3-甲氧基-2H-吲哚-2-酮。