We report the utility of cevipabulin as a stabilizing agent for microtubules. Cevipabulin-stabilized microtubules were more flexible compared to the microtubules stabilized by paclitaxel, the most commonly used microtubule stabilizing agent. Similar to the paclitaxel-stabilized microtubules, cevipabulin-stabilized microtubules were driven by kinesins in an in vitro gliding assay. The velocity of cevipabulin-stabilized microtubules was significantly higher than that of paclitaxel-stabilized microtubules. These findings will enrich the variety of microtubules with difference in mechanical and dynamic properties and widen their applications in nanotechnology.

中文翻译：

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Cevipabulin稳定微管。

我们报告了塞维帕布林作为微管稳定剂的效用。与紫杉醇（最常用的微管稳定剂）稳定的微管相比，塞维帕林稳定的微管具有更大的柔韧性。与紫杉醇稳定的微管相似，在体外滑行试验中，驱动蛋白驱动紫杉醇稳定的微管。Cevipabulin稳定的微管的速度明显高于紫杉醇稳定的微管的速度。这些发现将丰富具有不同机械和动态特性的微管，并扩大其在纳米技术中的应用。