4-Phenyl-3-furoxancarbonitrile (2) affords nitric oxide under the action of thiol cofactors. Two principal products were isolated in the reaction with thiophenol: the phenylcyanoglyoxime (6) and 5-amino-3-phenyl-4-(phenylthio)isoxazole (7). Mechanisms which could account for the formation of these two products are discussed. Compound 2 is an efficient activator of the rat lung soluble guanylate cyclase, displays high vasodilatory activity on strips of rat thoracic aorta precontracted with noradrenaline, and is a potent inhibitor of platelet aggregation.

中文翻译：

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呋喃烷作为一氧化氮供体。4-苯基-3-呋喃恶腈：硫醇介导的一氧化氮释放和生物学评估。

4-苯基-3-呋喃恶腈（2）在硫醇辅助因子的作用下生成一氧化氮。在与苯酚的反应中分离出两种主要产物：苯氰基肟（6）和5-氨基-3-苯基-4-（苯硫基）异恶唑（7）。讨论了可能解释这两种产品形成的机制。化合物2是大鼠肺可溶性鸟苷酸环化酶的有效激活剂，在与去甲肾上腺素预收缩的大鼠胸主动脉条上显示出高血管舒张活性，并且是有效的血小板聚集抑制剂。