The synthesis and antirhinovirus activity of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine (4 and 5) are reported. The structural assignments of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5. The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro. Both isomers inhibited multiplication of 15 different serotypes of rhinovirus.

中文翻译：

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6-[[[（羟基亚氨基）苯基]甲基] -1-[（1-甲基乙基）磺酰基] -1H-苯并咪唑-2-胺的正反异构体的合成。鼻病毒繁殖抑制剂。

报道了6-[[[（羟基亚氨基）苯基]甲基] -1-[（1-甲基乙基）磺酰基] -1H-苯并咪唑-2-胺（4和5）的顺式和反式异构体的合成和抗鼻病毒活性。4和5的结构分配基于两种异构体的13 C NMR光谱以及5的X射线分析。与之相比，抗异构体5在体外作为鼻病毒繁殖抑制剂比同型异构体4更有效。两种异构体均抑制了15种不同血清型的鼻病毒的繁殖。