Kadsurenone, a specific receptor antagonist of platelet-activating factor (PAF), and its analogues were prepared from derivatives of cinnamyl alcohol and (allyloxy)phenol. Racemic kadsurenone, resolvable by a Chiralpak column at low temperatures, has an IC50 value of 2 X 10(-7) M, which is about 50% of the activity of the natural product (IC50 = 1 X 10(-7) M). The structural specificity of kadsurenone was further demonstrated by the low PAF-receptor-blocking activities of denudatin B, mirandin A, desallylkadsurenone, and the 2-epimer of kadsurenone.

中文翻译：

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Kadsurenone类似物的构效关系。

Kadsurenone是一种血小板活化因子（PAF）的特异性受体拮抗剂，其类似物是由肉桂醇和（烯丙氧基）苯酚的衍生物制备的。外消旋的kadsurenone，在低温下可通过Chiralpak色谱柱分离，IC50值为2 X 10（-7）M，约为天然产物活性的50％（IC50 = 1 X 10（-7）M） 。DENudatin B，mirrandin A，desallylkadsurenone和kadsurenone的2-epimer的低PAF受体阻断活性进一步证明了kadsurenone的结构特异性。