A series of 3,4-dihydro-1H-1,4-oxazino[4,3-a]indoles bearing basic side chains has been synthesized by a novel chemical process. These compounds have been screened for potential antidepressant activity. One of these derivatives, 3,4-dihydro-1,10-dimethyl-1-(3-methylaminopropyl)-1H-1,4-oxazino[4,3-a]indole (AY-23,673), was particularly potent in the prevention of reserpine ptosis test in mice, with an ED50 of 0.5 mg/kg ip.

中文翻译：

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3,4-二氢-1H-1,4-恶嗪基[4,3-a]吲哚作为潜在的抗抑郁药。

通过新型化学方法合成了一系列带有碱性侧链的3,4-二氢-1H-1,4-恶嗪基[4,3-a]吲哚。已针对这些化合物的潜在抗抑郁活性进行了筛选。这些衍生物之一，3,4-二氢-1,10-二甲基-1-（3-甲基氨基丙基）-1H-1,4-恶嗪基[4,3-a]吲哚（AY-23,673）特别有效。 ED50为0.5 mg / kg ip的小鼠预防利血平上睑下垂测试。