A straightforward synthesis of ecteinascidin 743 was accomplished from readily available l-glutamic acid as a single chiral source. Our novel synthesis features a concise and convergent approach for construction of the B-ring, consisting of a sequence involving a stereoselective Heck reaction between a diazonium salt and an enamide, oxidative cleavage of the resulting alkene, and intramolecular ortho substitution of the phenol by an aldehyde.

中文翻译：

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海鞘素 743 的全合成

海鞘素 743 的直接合成是从容易获得的 l-谷氨酸作为单一手性来源完成的。我们的新合成具有构建 B 环的简洁和收敛的方法，包括一个序列，涉及重氮盐和烯酰胺之间的立体选择性 Heck 反应、所得烯烃的氧化裂解以及苯酚的分子内邻位取代醛。