血管内皮生长因子（VEGF）/可溶性VEGF受体-1的关系在乳腺癌中的意义。,International Journal of Cancer

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血管内皮生长因子（VEGF）/可溶性VEGF受体-1的关系在乳腺癌中的意义。
International Journal of Cancer ( IF 5.7 ) Pub Date : 2002-02-22 , DOI: 10.1002/ijc.10121
Masakazu Toi ₁ , Hiroko Bando , Taeko Ogawa , Mariko Muta , Carsten Hornig , Herbert A Weich

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血管生成，即新血管的形成，受内皮调节因子正负之间的平衡控制。可溶性血管内皮生长因子受体1（sVEGFR1）是VEGFR1的天然可溶形式，是血管内皮生长因子（VEGF）信号通路的负向对应物，已被表征为人类最重要的内皮调节因子之一肿瘤血管生成。在我们的研究中，我们检查了sVEGFR1在110例原发性乳腺癌中的表达，并评估了其临床意义。通过特异性酶联免疫吸附测定（ELISA）确定的110个肿瘤中的94个显示sVEGFR1蛋白>或= 0.1 ng / mg（范围：0。1-6.9 ng / mg蛋白;中位数：1.03 ng / mg蛋白））。免疫印迹分析证实了乳腺癌组织中存在sVEGFR1。sVEGFR1的水平与VEGF的水平显着相关。sVEGFR1水平与任何临床病理因素（包括年龄，更年期，淋巴结受累和激素受体状态）之间均无显着相关性。单因素预后分析显示，通过ELISA确定的肿瘤内VEGF状态是重要的预后指标，而sVEGFR1状态则不是。然而，在组合分析中，sVEGFR1和VEGF水平的比值比单独的VEGF状态具有更高的统计学意义。sVEGFR1水平超过VEGF水平10倍的肿瘤的预后非常好。多变量分析还表明，sVEGFR1和VEGF的比例是淋巴结转移后的独立预后指标。总之，sVEGFR1 VEGF的一种内在抑制剂，通常在原发性乳腺癌组织中与VEGF共表达。sVEGFR1和VEGF水平之间的肿瘤内平衡可能对乳腺癌的进展至关重要。

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Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor-1 relationship in breast cancer.

Angiogenesis, the formation of new blood vessels, is controlled by a balance between positive and negative endothelial regulatory factors. Soluble vascular endothelial growth factor receptor-1 (sVEGFR1), a naturally occurring soluble form of VEGFR1, is a negative counterpart of the vascular endothelial growth factor (VEGF) signaling pathway, which has been characterized as one of the most important endothelial regulators in human tumor angiogenesis. In our study, we examined the expression of sVEGFR1 in 110 primary breast carcinomas, and assessed its clinical significance. Ninety-four of 110 tumors showed > or = 0.1 ng/mg protein of sVEGFR1 (range:0. 1-6.9 ng/mg protein; median: 1.03 ng/mg protein) as determined by a specific enzyme-linked immunosorbent assay (ELISA). Immunoblot analysis confirmed the presence of sVEGFR1 in breast tumor tissues. The levels of sVEGFR1 were correlated significantly with the levels of VEGF. There was no significant correlation between the levels of sVEGFR1 and any clinico-pathological factors including age, menopause, nodal involvement and hormone receptor status. A univariate prognosis analysis showed that the intratumoral VEGF status, as determined by ELISA, was a significant prognostic indicator, but sVEGFR1 status was not. In the combined analysis, however, the ratio of sVEGFR1 and VEGF levels provided more statistically significant prognostic value than VEGF status alone. Tumors in which the sVEGFR1 levels exceeded VEGF levels 10-fold had a markedly favorable prognosis. Multivariate analysis also demonstrated that the ratio of sVEGFR1 and VEGF was an independent prognostic indicator after nodal status. In conclusion, sVEGFR1, an intrinsic inhibitor of VEGF, frequently co-expressed with VEGF in primary breast cancer tissues. The intratumoral balance between sVEGFR1 and VEGF levels might be crucial for the progression of breast cancer.

更新日期：2019-11-01

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