Five metabolites tentatively called GS-1 (1)-5 (5) from Gelasinospora santi-florii, and four tentatively called EQ-4 (6), EQ-6 (7)-8 (9) together with 1-4 from Emericella quadrilineata have been isolated in a screening study on immunomodulatory fungal constituents. Among these nine metabolites, EQ-7 and 8 have been unknown. This time, the structures of GS-4 which has previously been isolated, EQ-7, and -8 have been determined to be (4R,4aS,9aR)-1,9a-dihydronidulalin A (4), (4S,4aR,9aR)-4a-carbomethoxy-1,4,4a,9a-tetrahydro-4,8-dihydroxy-6-methylxanthone (8), and 9-hydroxymicroperfuranone (9), respectively, and the six other metabolites have been identified. On bioassay, a dihydroxanthone, nidulalin A (1), a hexaketide, sordarial (5), and a xanthone, pinselin (7) have displayed significant immunosuppressive activities. The structure-activity relationships of these constituents have also been discussed.

中文翻译：

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在一项针对免疫调节活性的筛选研究中发现了九种成分，其中包括从两种子囊菌中分离出的六种黄酮相关化合物，即Gelasinospora santi-florii和Emericella quadrilineata。

五个代谢物暂定为来自Gelasinospora santi-florii的GS-1（1）-5（5），四个暂定称为EQ-4（6），EQ-6（7）-8（9）和Emericella的1-4在对免疫调节性真菌成分的筛选研究中已分离出四线莲。在这9种代谢物中，EQ-7和8未知。这次，先前已分离的GS-4，EQ-7和-8的结构已确定为（4R，4aS，9aR）-1,9a-二氢鸟苷（A）（4），（4S，4aR， 9aR）-4a-碳甲氧基-1,4,4a，9a-四氢-4,8-​​二羟基-6-甲基x吨酮（8）和9-羟基微呋喃酮（9）以及其他六种代谢物已被鉴定。在生物测定中，二氢黄酮，尼杜拉林A（1），己酮，sordarial（5）和黄酮，松脂（7）表现出显着的免疫抑制活性。