Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoning are reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as well as the pathways affected by lead poisoning are not completely described. The aim of this study was to construct a map of metabolic pathways impaired in lead poisoning by evaluating which biomolecules are directly affected by lead. Through manual literature curation, we identified proteins which physically interact with lead and subsequently determined the metabolic pathways those proteins are involved with. At total, we identified 23 proteins involved with heme synthesis, calcium metabolism, neurotransmission, among other biological systems, which helps to understand the wide range of lead-poisoning symptoms.

铅是一种重要的重金属，在全球范围内被广泛应用，尤其是在工业中。接触铅的人会出现与铅中毒有关的多种症状。文献报道了铅中毒的许多影响，显示出危害全身健康的症状，涉及心血管，免疫，骨骼，生殖，血液，肾脏，胃肠道和神经系统。但是，分子铅靶标以及受铅中毒影响的途径尚未完全描述。这项研究的目的是通过评估哪些生物分子直接受到铅的影响来构建铅中毒受损的代谢途径图。通过手工文献策划，我们鉴定了与铅发生物理相互作用的蛋白质，并随后确定了这些蛋白质所涉及的代谢途径。总体而言，我们鉴定出23种与血红素合成，钙代谢，神经传递以及其他生物系统有关的蛋白质，这有助于理解各种铅中毒症状。