BACKGROUND Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-sensing ion channels (ASICs) are being attributed to an increasingly larger significance in pain aetiology. Over the last few years, the mechanism of ASICs action, influence of their antagonists/agonists and clinical applications have been well described. However, the importance of this protein is significantly larger, not only from the perspective of pain management, but also in psychiatry of addiction or fear. Recently discovered peptides from three-finger toxin group, called mambalgins (isolated from Dendroaspis polylepis polylepsis) exhibit potent analgesic mechanisms of action on ASICs in animal model. AIMS & METHODS The article reviews current knowledge in the field of mambalgins and assesses their potential analgesic application, based on the recent experimental evidence. RESULTS The mambalgins seem to decrease the intensity of the inflammatory, neuropathic and mechanic pain. This has been demonstrated in animal studies of different pain models, including carrageenan- induced inflammatory pain, chronic constrictive injury-induced neuropathic pain and thermal pain. The mechanism of mambalgin action is not clearly defined, but it is suspected that they bind directly to the pH-sensitive region of the ASIC. CONCLUSION In this short review, we attempted to summarise the current knowledge about mambalgins and their potential applications as a new substance in searching for the ideal analgesia without common side effects of the other drug groups.

中文翻译：

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Mambalgins，作为一种可能是新型镇痛药的毒液肽：Mini Review。

背景技术尽管目前有各种各样的镇痛方案，但是慢性疼痛是难以治疗的疾病。它的病理生理学，启动，发展和过程涉及一系列不同的受体和递质。酸敏感离子通道（ASICs）在疼痛病因学中的重要性越来越高。在过去的几年中，ASIC的作用机理，其拮抗剂/激动剂的影响以及临床应用已得到了很好的描述。但是，不仅从疼痛控制的角度来看，而且在成瘾或恐惧的精神病学方面，这种蛋白质的重要​​性也显着提高。最近发现的三指毒素组肽，称为曼巴金（Mambolgins）（分离自多毛树菌（Dendroaspis polylepis polylepsis））对动​​物模型中的ASIC具有有效的镇痛作用。目的与方法本文根据最新的实验证据，回顾了曼博尔青素领域的最新知识，并评估了其在镇痛药中的潜在应用。结果曼巴宁似乎减轻了炎症性，神经性和机械性疼痛的强度。在不同疼痛模型的动物研究中已证明了这一点，这些模型包括角叉菜胶引起的炎症性疼痛，慢性收缩性损伤引起的神经性疼痛和热痛。mambalgin作用的机制尚不清楚，但是怀疑它们直接与ASIC的pH敏感区域结合。结论在这篇简短的评论中，