AK-968 is a small molecular weight compound. In this study, we evaluated its anti-tumor effects on human multiple myeloma (MM) cells. Our results demonstrated that AK-968 markedly inhibited proliferation of MM cell lines in a dose-and time-dependent manner. Additionally, our flow cytometry data showed that MM cell apoptosis was significantly induced by AK-968. As expected, caspase-3 cleavage and alternation of mitochondrial membrane potential (MMP) in the MM cells treated by AK-968 was detected or quantified by Western Blot or Flow cytometry technique, respectively. In conclusion, our results suggested that AK-968 may act as a potential drug to treat human multiple myeloma.

中文翻译：

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AK-968在人多发性骨髓瘤细胞中有效抑制增殖并诱导细胞凋亡。

AK-968是一种小分子量化合物。在这项研究中，我们评估了其对人类多发性骨髓瘤（MM）细胞的抗肿瘤作用。我们的结果表明，AK-968以剂量和时间依赖性方式显着抑制MM细胞系的增殖。此外，我们的流式细胞仪数据显示AK-968显着诱导了MM细胞凋亡。如预期的那样，分别通过Western Blot或流式细胞术检测或定量了AK-968处理的MM细胞中的caspase-3裂解和线粒体膜电位（MMP）的变化。总之，我们的结果表明AK-968可能是治疗人类多发性骨髓瘤的潜在药物。