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Palmitoylcarnitine, a surface-active metabolite
FEBS Letters ( IF 3.0 ) Pub Date : 1996-07-15 , DOI: 10.1016/0014-5793(96)00603-5
F M Goñi 1 , M A Requero , A Alonso
Affiliation  

Palmitoylcarnitine is a well‐known intermediate in mitochondrial fatty acid oxidation. Less known are its properties as a surfactant, with a capacity to solubilize biological membranes similar to that of many synthetic detergents used in the biochemical laboratory. Some of the physico‐chemical properties of palmitoylcarnitine may help to explain the need for coenzyme A‐carnitine‐coenzyme A acyl exchange during mitochondrial fatty acid import. The amphiphilic character of palmitoylcarnitine may also explain its proposed involvement in the pathogenesis of myocardial ischemia.

中文翻译:

棕榈酰肉碱,一种表面活性代谢物

棕榈酰肉碱是众所周知的线粒体脂肪酸氧化中间体。鲜为人知的是它作为表面活性剂的特性,具有溶解生物膜的能力,类似于生化实验室中使用的许多合成洗涤剂。棕榈酰肉碱的一些理化特性可能有助于解释在线粒体脂肪酸输入过程中需要辅酶 A-肉碱-辅酶 A 酰基交换。棕榈酰肉碱的两亲性特征也可以解释其参与心肌缺血的发病机制。
更新日期:1996-07-15
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