止血剂对拔牙窝早期愈合的作用。,Journal of Clinical Periodontology

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止血剂对拔牙窝早期愈合的作用。
Journal of Clinical Periodontology ( IF 5.8 ) Pub Date : 2019-07-01 , DOI: 10.1111/jcpe.13122
Xiaodong Guo ₁ , Haikun Hu ₂ , Yindong Liu ₁ , Chongyun Bao ₁ , Liao Wang ₁

Affiliation

目的本研究旨在探讨两种市售止血剂（即胶原海绵和氧化物纤维素）对拔牙窝早期愈合的作用。材料与方法在鼠模型中，提取双侧上颌第一磨牙，并在窝中填充止血剂或不使用止血剂。在提取后第1、3、7和14天采集的样品上进行了组织学，组织形态计量学和免疫染色测定。还设计了体外研究来研究试剂对pH动态和细胞活力的影响。结果两种药物均延迟了早期的窝愈合，但是方式不同。与胶原蛋白和对照组相比，提取后第1天氧化物纤维素阻碍了细胞的迁移。两种材料均延迟了细胞的增殖和成骨分化。此外，止血剂组中存在牙周膜细胞的凋亡。这些作用归因于两种药剂对牙周膜的压缩，氧化物纤维素引起的酸性生态位以及药剂引起的强烈的异物反应和炎症反应。结论止血剂的放置通过不同的生物学机制延迟了早期拔牙窝的愈合。以及由药剂引起的强烈异物反应和炎症反应。结论止血剂的放置通过不同的生物学机制延迟了早期拔牙窝的愈合。以及由药剂引起的强烈异物反应和炎症反应。结论止血剂的放置通过不同的生物学机制延迟了早期拔牙窝的愈合。

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The effect of haemostatic agents on early healing of the extraction socket.

AIM This study aims to explore the effect of two commercially available haemostatic agents (i.e., collagen sponge and oxide cellulose) on early healing of the extraction socket. MATERIAL AND METHODS In a murine model, bilateral maxillary first molars were extracted and the sockets were filled with or without haemostatic agents. Histology, histomorphometry and immunostaining assays were performed on samples harvested on postextraction day 1, 3, 7 and 14. In vitro studies were also designed to investigate the effect of agents on the dynamics of pH and viability of cells. RESULTS Early socket healing was delayed by both agents but with different patterns. The migration of cells was impeded by oxide cellulose on postextraction day 1 compared with the collagen and the control group. The proliferation and osteogenic differentiation of cells were delayed by both materials. Moreover, apoptosis of periodontal ligament cells was present in the haemostatic agent groups. These effects are attributed to the compression to periodontal ligament by both agents, the acidic niche caused by oxide cellulose, and the intense foreign body reaction and inflammatory response caused by the agents. CONCLUSIONS The placement of haemostatic agents delay the early extraction socket healing via different biological mechanism.

更新日期：2019-11-01

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