Nr5a2通过Wnt /β-catenin信号传导促进胃癌AGS细胞的肿瘤生长和转移。,OncoTargets and Therapy

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Nr5a2通过Wnt /β-catenin信号传导促进胃癌AGS细胞的肿瘤生长和转移。
OncoTargets and Therapy ( IF 2.7 ) Pub Date : 2019-05-23 , DOI: 10.2147/ott.s201228
Lei Liu _{1,

2,

3} , Yan Li ₄ , Biran Pan _{1,

2,

3} , Tongtong Zhang _{1,

2,

3} , Danfeng Wei _{1,

2,

3} , Yifang Zhu _{1,

2,

3} , Yuanbiao Guo _{1,

2,

3}

Affiliation

目的：Nr5a2（核受体亚家族5组2成员，也称为LRH-1）属于核受体的NR5A（Ftz-F1）亚家族，是干细胞多能性和几种类型发育的关键调节剂。癌症。但是，这些数据存在争议。由于Nr5a2在多种类型的癌症中起着不同的作用，并且尚未揭示Nr5a2在胃癌（GC）中的功能，因此我们研究了Nr5a2在GC中的作用和分子机制。方法：在这项研究中，我们通过体内和体外模型研究了Nr5a2对肿瘤生长和转移的影响。结果：结果表明，敲低Nr5a2可以通过阻止G2 / M期的细胞周期抑制细胞增殖，并通过防止AGS细胞的上皮-间质转化（EMT）过程抑制细胞迁移。此外，Nr5a2的基因敲低可以抑制AGS细胞的体内肿瘤发生和转移。我们还证明了通过抑制Wnt /β-catenin信号传导途径抑制Nr5a2抑制细胞增殖和迁移。结论：Nr5a2可能是GC开发中的致癌基因。EMT过程和Wnt /β-catenin信号通路在Nr5a2诱导的GC发育中起重要作用。

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Nr5a2 promotes tumor growth and metastasis of gastric cancer AGS cells by Wnt/beta-catenin signaling.

Purpose: Nr5a2 (nuclear receptor subfamily 5 group A member 2, also known as LRH-1), which belongs to the NR5A (Ftz-F1) subfamily of nuclear receptors, is a key regulator in stem cell pluripotency and the development of several types of cancer. However, the data are controversial. Since Nr5a2 plays different roles in multiple types of cancer and the function of Nr5a2 in gastric cancer (GC) has not been revealed, we studied the role and molecular mechanism of Nr5a2 in GC. Methods: In this study, we have investigated the effect of Nr5a2 on tumor growth and metastasis by in vivo and in vitro models. Results: The results showed that knockdown of Nr5a2 could inhibit cell proliferation via arresting the cell cycle in the G2/M phase and suppress cell mobility through preventing the epithelial-mesenchymal transition (EMT) process in AGS cells. In addition, knockdown of Nr5a2 could suppress tumorigenesis and metastasis of AGS cells in vivo. We also demonstrated that knockdown of Nr5a2 inhibited cellular proliferation and mobility by suppressing the Wnt/beta-catenin signaling pathway. Conclusion: Nr5a2 may act as an oncogene in GC development. The EMT process and the Wnt/beta-catenin signaling pathway play an important role in the Nr5a2 induced GC development.

更新日期：2019-11-01

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