L-Glutamine: D-fructose-6-phosphate amidotransferase, known under trivial name of glucosamine-6-phosphate synthase, as the only member of the amidotransferase subfamily of enzymes, does not display any ammonia-dependent activity. This enzyme, catalysing the first committed step in a pathway leading to the eventual formation of uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), is an important point of metabolic control in biosynthesis of amino sugar-containing macromolecules. The molecular mechanism of reaction catalysed by GlcN-6-P synthase is complex and involves both amino transfer and sugar isomerisation. Substantial alterations to the enzyme structure and properties have been detected in different neoplastic tissues. GlcN-6-P synthase is inflicted in phenomenon of hexosamine-induced insulin resistance in diabetes. Finally, this enzyme has been proposed as a promising target in antifungal chemotherapy. Most of these issues, especially their molecular aspects, have been extensively studied in recent years. This article provides a comprehensive overview of the present knowledge on this multi-facets enzyme.

中文翻译：

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氨基葡萄糖6-磷酸合酶-多方面的酶。

L-谷氨酰胺：D-果糖6-磷酸酰胺基转移酶，俗称葡糖胺6-磷酸合酶，是酶酰胺基转移酶亚家族的唯一成员，不显示任何氨依赖性活性。这种酶催化尿苷5'-二磷酸-N-乙酰基-D-葡萄糖胺（UDP-GlcNAc）最终形成的途径中的第一步，是代谢控制含氨基糖的重要过程大分子。GlcN-6-P合酶催化的反应的分子机制很复杂，涉及氨基转移和糖异构化。在不同的肿瘤组织中已检测到酶结构和性质的实质性改变。在糖尿病中，GlcN-6-P合酶引起了己糖胺诱导的胰岛素抵抗现象。最后，该酶已被提议作为抗真菌化疗的有希望的靶标。这些问题中的大多数，特别是它们的分子方面，近年来已得到广泛研究。本文提供了有关此多方面酶的当前知识的全面概述。