Abstract

Two new monoterpene esters illigerates F and G (1 and 2) together with 5 know compounds illigerate A (3), illigerate C (4), actinodaphnine (5), N-methylactinodaphnine(6) and N-methyllaurotetanine(7) were isolated from Illigera aromatica S. Z. Huang et S. L. Mo. Their structures were identified by extensive NMR data and by comparing with the known compounds. The anti-inflammatory activity of four monoterpenes (1 - 4) was evaluated by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated murine macrophage RAW 264.7 cells and four monoterpenoids exhibited inhibitory effect with IC₅₀ values of 71.5 ± 7.3, 74.7 ± 5.6, 48.0 ± 7.4 and 65.1 ± 3.7 μM, respectively.

抽象的

分离出两个新的单萜酸酯类化合物F和G（1和2），以及5种已知化合物，它们分别为A（3），C（4），放线菌碱（5），N-甲基放线菌碱（6）和N-甲基月桂丹宁（7）从青藤郁金SZ Huang等SL的Mo.其结构经广泛NMR数据，并通过与已知化合物进行比较来标识。四个单萜（抗炎活性1 - 4通过抑制脂多糖激活的鼠巨噬细胞RAW 264.7细胞中一氧化氮（NO）的产生来评估），并且四个单萜类化合物表现出抑制作用，IC ₅₀值分别为71.5±7.3、74.7±5.6、48.0±7.4和65.1±3.7μM。