猪圆环病毒：综述。,The Journal of Veterinary Diagnostic Investigation

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猪圆环病毒：综述。
The Journal of Veterinary Diagnostic Investigation ( IF 1.2 ) Pub Date : 2000-02-26 , DOI: 10.1177/104063870001200102
G M Allan ₁ , J A Ellis

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猪圆环病毒（PCV）是小型非包膜DNA病毒，包含独特的单链环状基因组。以前，在猪的PCV感染与疾病之间没有发现公认的联系，并且PCV被认为是非病原体。在过去的5年中，一种称为PCV2的“新型” PCV与猪的各种疾病综合征相关，主要是断奶后多系统浪费综合征（PMWS）。患有PMWS的猪具有多种临床体征，包括虚弱，呼吸困难，明显的淋巴结病，腹泻和苍白或黄疸。与PCV2在多种细胞类型中存在相关的病变包括淋巴组织细胞性肉芽肿性间质性肺炎，肝炎，肾炎，心肌炎，肠炎和胰腺炎。尽管用综合征病毒的完全表达可能需要存在其他因子，例如猪细小病毒或猪生殖与呼吸综合征（PRRS）病毒，但是PMWS的损伤已在实验猪的PCV2细胞培养分离物中接种了。最近的报道将PCV2与猪的其他疾病相关，从流产和生殖衰竭到“非典型” PRRS。现有数据表明全世界PCV2抗体的血清阳性率很高。PCV2相关疾病的诊断基于受影响组织中PCV2抗原或核酸的直接证明。现在，PCV2被视为重要的新兴病原体。尽管有垂直传播的记录，但对PCV2感染的流行病学了解甚少，

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Porcine circoviruses: a review.

Porcine circoviruses (PCV) are small nonenveloped DNA viruses containing a unique single-stranded circular genome. Previously, no recognized link was found between PCV infection of pigs and disease, and PCV was considered a nonpathogenic agent. Over the last 5 years, a "novel" PCV, designated PCV2, has been associated with various disease syndromes in pigs, primarily postweaning multisystemic wasting syndrome (PMWS). Pigs with PMWS have a variety of clinical signs, including debility, dyspnea, palpable lymphadenopathy, diarrhea, and pallor or icterus. Lesions associated with the presence of PCV2 in a variety of cell types include lymphohistiocytic to granulomatous interstitial pneumonia, hepatitis, nephritis, myocarditis, enteritis, and pancreatitis. The lesions of PMWS have been reproduced experimentally after inoculation of piglets with PCV2 cell culture isolates, although the full expression of the disease syndrome may require the presence of other agents such as porcine parvovirus or porcine reproductive and respiratory syndrome (PRRS) virus. Recent reports have linked PCV2 to other disorders in pigs, ranging from abortion and reproductive failure to "atypical" PRRS. Available data indicate high seroprevalence of antibodies to PCV2 worldwide. The diagnosis of PCV2-associated disease is based on the direct demonstration of PCV2 antigens or nucleic acid in affected tissues. PCV2 is now regarded as an important emerging pathogen. Although vertical transmission has been documented, the epidemiology of PCV2 infections is poorly understood, as is the role of the immune response in controlling or augmenting disease.

更新日期：2019-11-01

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