Abstract

A pair of new neo-clerodane diterpenoid epimers, 3S-methoxyl-teucvin (1) and 3R-methoxyl-teucvin (2), were isolated from the Roots of Croton crassifolius. Their structures were completely established on the basis of spectroscopic methods, and the absolute configurations were determined by analysis of electronic circular dichroism (ECD) spectroscopy and X-ray diffraction analysis. Compounds 1 and 2 exhibited anti-inflammatory activities with IC₅₀ values of 0.82 and 0.54 μM, respectively, while the IC₅₀ value of dexamethasone as a positive control was found to be 0.14 μM.

中文翻译：

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巴豆crassifolius的根中的一对新的新的新环戊烷二萜类差向异构体及其抗炎作用。

摘要

从巴豆crassifolius的根中分离出一对新的新环戊烷二萜差向异构体，即3 S-甲氧基-teucvin（1）和3 R-甲氧基-teucvin（2）。它们的结构是在光谱学方法的基础上完全建立的，并且通过电子圆二色谱（ECD）光谱分析和X射线衍射分析确定了绝对构型。化合物1和2表现出抗炎活性，IC ₅₀值分别为0.82和0.54μM，而地塞米松作为阳性对照的IC ₅₀值为0.14μM。